Performance
Planned Research
A01：Analysis, quantification, and visualization of supersulfides
A02：Electron flux mediated by supersulifdes
A03：Signal transduction utilizing supersulfides
Publicly Offered Research
A01：Analysis, quantification, and visualization of supersulfides
A02：Electron flux mediated by supersulifdes
A03：Signal transduction utilizing supersulfides
B01：Highly interdisciplinary research related to sulfur
Publication list
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A01 Hidehiko Nakagawa
Original paper Mitsuyasu Kawaguchi, Yuri Furuse, Naoya Ieda, and Hidehiko Nakagawa.
Development of Nucleoside Diphosphate-Bearing Fragile Histidine Triad-Imaging Fluorescence Probes with Well-Tuned Hydrophobicity for Intracellular Delivery.
ACS Sensors, 7, 2022
10.1021/acssensors.2c01273: https://doi.org/10.1021/acssensors.2c01273Original paper Kazuya Matsuo, Sampreeth Thayyil, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, and Nobuyuki Tamaoki.
A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole.
Chem. Commun., 57, 2021
10.1039/D1CC04905D: https://doi.org/10.1039/D1CC04905DOriginal paper Naoya Ieda, Yuka Yoshikawa, Natsumi Tomita, Kei Ohkubo, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, and Hidehiko Nakagawa.
Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation.
Chem. Commun., 58, 2022
10.1039/D2CC03193K: https://doi.org/10.1039/D2CC03193KOriginal paper Kan'ichiro Ishiuchi, Akiho Nagumo, Mitsuyasu Kawaguchi, Honoka Furuyashiki, Hidehiko Nakagawa, and Dai Hirose.
Stereochemistries of Mariannamides C and D, Two Lipohexapeptides, Isolated from Mariannaea elegans NBRC102301.
Heterocycles, 104, 2022
10.3987/COM-22-14728: https://www.heterocycles.jp/newlibrary/payments/form/27733/PDFwithLinksOriginal paper Keisuke Maeda, Makoto Habara, Mitsuyasu Kawaguchi, Hiroaki Matsumoto, Shunsuke Hanaki, Takahiro Masaki, Yuki Sato,
Hideyasu Matsuyama, Kazuki Kunieda, Hidehiko Nakagawa, and Midori Shimada.
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
Molecular Oncology, 16, 2022
10.1002/1878-0261.13030: https://doi.org/10.1002/1878-0261.13030Original paper Tachibana K, Kusumoto K, Ogawa M, Ando H, Shimizu T, Ishima Y, Ishida T, Okuhira K.
FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages.
Int J Mol Sci., 23(23), 2022
10.3390/ijms232314617: https://doi.org/10.3390/ijms232314617Original paper Ishima Y, Yamazaki N, Chuang VTG, Shimizu T, Ando H, Ishida T.
A Maleimide-Terminally Modified PEGylated Liposome Induced the Accelerated Blood Clearance Independent of the Production of Anti-PEG IgM Antibodies.
Biol Pharm Bull., 45(10), 2022
10.1248/bpb.b22-00389: https://doi.org/10.1248/bpb.b22-00389Original paper Beppu T, Nishi K, Imoto S, Araki W, Setoguchi I, Ueda A, Suetsugi N, Ishima Y, Ikeda T, Otagiri M, Yamasaki K.
Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts.
Oncol Rep., 48(4), 2022
10.3892/or.2022.8393: https://doi.org/10.3892/or.2022.8393Original paper Ando H, Ikeda A, Tagami M, Matsuo NCA, Shimizu T, Ishima Y, Eshima K, Ishida T.
Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment.
J Control Release., 350, 2022
10.1016/j.jconrel.2022.08.031: https://doi.org/10.1016/j.jconrel.2022.08.031Original paper Kawaguchi Y, Shimizu T, Ando H, Ishima Y, Ishida T.
Development of a Nanocarrier-Based Splenic B Cell-Targeting System for Loading Antigens in Vitro.
Biol Pharm Bull., 45(7), 2022
10.1248/bpb.b22-00222: https://doi.org/10.1248/bpb.b22-00222Original paper Tanaka Y, Okuyama H, Nishikawa M, Ikushiro SI, Ikeda M, Ishima Y, Ukawa Y, Oe K, Terao J, Mukai R.
8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells.
Food Sci Nutr., 10(4), 2022
10.1002/fsn3.2733: https://doi.org/10.1002/fsn3.2733Original paper Nishi K, Imoto S, Beppu T, Uchibori S, Yano A, Ishima YU, Ikeda T, Tsukigawa K, Otagiri M, Yamasaki K.
The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism.
Anticancer Res., 42(3), 2022
10.21873/anticanres.15601: https://ar.iiarjournals.org/content/42/3/1333Original paper El Sayed MM, Shimizu T, Abu Lila AS, Elsadek NE, Emam SE, Alaaeldin E, Kamal A, Sarhan HA, Ando H, Ishima Y, Ishida T.
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes.
Int J Pharm., 615, 2022
10.1016/j.ijpharm.2022.121539: https://doi.org/10.1016/j.ijpharm.2022.121539Original paper Nakajima T, Nagano K, Fukuda Y, Ishima Y, Shibata H, Isaka R, Zhang TQ, Haga Y, Higashisaka K, Tsujino H, Ishida T, Ishii-Watabe A, Tsutsumi Y.
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.
J Pharm Sci., 111(5), 2022
10.1016/j.xphs.2022.01.023: https://doi.org/10.1016/j.xphs.2022.01.023Original paper Mostafa M, Elsadek NE, Emam SE, Ando H, Shimizu T, Abdelkader H, Ishima Y, Aly UF, Sarhan HA, Ishida T.
Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation.
Biol Pharm Bull., 45(1), 2022
10.1248/bpb.b21-00772: https://doi.org/10.1248/bpb.b21-00772Original paper Ando-Matsuoka R, Ando H, Abu Lila AS, Maeda N, Shimizu T, Ishima Y, Ishida T.
I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors.
J Control Release., 341, 2022
10.1016/j.jconrel.2021.12.004: https://doi.org/10.1016/j.jconrel.2021.12.004Original paper Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T.
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH.
J Control Release., 341, 2022
10.1016/j.jconrel.2021.11.039: https://doi.org/10.1016/j.jconrel.2021.11.039Original paper Keitaro Umezawa, Hiroki Tsumoto, Kyojiro Kawakami, Yuri Miura.
A chemical probe for proteomic analysis and visualization of intracellular localization of lysine-succinylated proteins.
Analyst, 148, 2023
10.1039/D2AN01370C: https://pubs.rsc.org/en/content/articlelanding/2023/an/d2an01370c
Review Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T.
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.
J Control Release., 351, 2022
10.1016/j.jconrel.2022.09.031: https://doi.org/10.1016/j.jconrel.2022.09.031
Review Matsuo NCA, Ando H, Doi Y, Shimizu T, Ishima Y, Ishida T.
The Challenge to Deliver Oxaliplatin (l-OHP) to Solid Tumors: Development of Liposomal l-OHP Formulations.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c22-00099: https://doi.org/10.1248/cpb.c22-00099
Review Shimizu T, Kawaguchi Y, Ando H, Ishima Y, Ishida T.
Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c22-00047: https://doi.org/10.1248/cpb.c22-00047
Review Ishima Y, Maruyama T, Otagiri M, Chuang VTG, Ishida T.
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c21-01024: https://doi.org/10.1248/cpb.c21-01024
A01 Kei Wada
Original paper Tatsuya Joutsuka, Ryota Nanasawa, Keisuke Igarashi, Kazuki Horie, Masakazu Sugishima, Yoshinori Hagiwara, Kei Wada, Keiichi Fukuyama, Naomine Yano, Seiji Mori, Andreas Ostermann, Katsuhiro Kusaka, and Masaki Unno.
Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states.
J. Biol. Chem., in press., 2022
10.1016/j.jbc.2022.102763: https://doi.org/10.1016/j.jbc.2022.102763
Original paper Michiko Takahashi, Kei Wada, Syun-ichi Urayama, Yuichi Masuda, Keizo Nagasaki.
Degenerate PCR Targeting the Major Capsid Protein Gene of HcRNAV and Related Viruses.
Microbes and Environments, 37(5), ME21075, 2022
10.1264/jsme2.ME21075: https://doi.org/10.1264/jsme2.ME21075
Original paper Ishizaka M, Chen M, Narai S, Tanaka Y, Ose T, Horitani M, and Yao M.
Rapid and spontaneous transformation between [3Fe–4S] and [4Fe–4S] iron–sulfur clusters in the tRNA-thiolation enzyme TtuA.
International Journal of Molecular Sciences. Accepted, 2022
Original paper Hishinuma E, Narita Y, Rico E.G, Ueda A, Obuchi K, Tanaka Y, Saito S, Tadaka S, Kinoshita K, Maekawa M, Mano N, Nakayoshi T, Oda A, Hirasawa N, and Hiratsuka M.
Functional characterization of 12 dihydropyrimidinase allelic variants in Japanese individuals for the prediction of 5-fluorouracil treatment-related toxicity.
Drug Metabolism and Disposition. Accepted(2022), 51(2), 2023
10.1124/dmd.122.001045: https://dmd.aspetjournals.org/content/51/2/165
Original paper Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia P.J, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann D.M, Imai M, Komatsu N, Araki M, Tanaka Y, Sakai R.
A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-34921-2: https://www.nature.com/articles/s41467-022-34921-2
Original paper Kodama K, Rich M.K, Yoda A, Shimazaki S, Xie X, Akiyama K, Mizuno Y, Komatsu A, Luo Y, Suzuki H, Kameoka H, Libourel C, Keller J, Sakakibara K, Nishiyama T, Nakagawa T, Mashiguchi K, Uchida K, Yoneyama K, Tanaka Y, Yamaguchi S, Shimamura M, Delaux P.-M,
Nomura T, Kyozuka J.
An ancestral function of strigolactones as symbiotic rhizosphere signals.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-31708-3: https://www.nature.com/articles/s41467-022-31708-3
Original paper Tsugita A, Uehara S, Matsui T, Yokoyama T, Ostash I, Deneka M, Yalamanchili S, Bennett C.S, Tanaka Y, Ostash B.
The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK.
FEBS Journal, 289, 19, 2022
10.1111/febs.16460: https://doi.org/10.1111/febs.16460
Original paper Ghanem N, Kanagami N, Matsui T, Takeda K, Kaneko J, Shiraishi Y, Choe C.A, Uchikubo-Kamo T, Shirouzu M, Hashimoto T, Ogawa T, Matsuura T, Huang P.-S, Yokoyama T, Tanaka Y.
Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain.
FEBS Journal, 289, 12, 2022
10.1111/febs.16354: https://doi.org/10.1111/febs.16354
Original paper Tagami T, Chen M, Furunaga Y, Kikuchi A, Sadahiro J, Lang W, Okuyama M, Tanaka Y, Iwasaki T, Yao M, and Kimura A.
Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
The FEBS J., 289, 2022
10.1111/febs.16237: https://doi.org/10.1111/febs.16237
A01 Takakazu Nakabayashi
Original paper Kosuke Yamazaki, Shinya Tahara, Takumi Ohyama, Kunisato Kuroi, Takakazu Nakabayashi.
SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage.
Scientific Reports, 12, 1, 2022
10.1038/s41598-022-15701-w: https://www.nature.com/articles/s41598-022-15701-w
Original paper Kohei Yokosawa, Shinji Kajimoto, Daiki Shibata, Kunisato Kuroi, Tomohiro Konno, Takakazu Nakabayashi.
Concentration Quantification of the Low-Complexity Domain of Fused in Sarcoma inside a Single Droplet and Effects of Solution Parameters.
Journal of Physical Chemistry Letters, 13, 24, 2022
10.1021/acs.jpclett.2c00962: https://doi.org/10.1021/acs.jpclett.2c00962
A01 Kenjiro Hanaoka
Original paper Hoshino Y, Hanaoka K, Sakamoto K, Yasunaga M, Kojima T, Kotani D, Nomoto A, Sasaki E, Komatsu T, Ueno T, Takamaru H, Saito Y, Seto Y, Urano Y.
Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity.
RSC Chemical Biology, 3, 7, 2022
10.1039/d1cb00253h: https://pubs.rsc.org/en/content/articlelanding/2022/cb/d1cb00253h#fn1
Original paper Hanaoka K, Iwaki S, Yagi K, Myochin T, Ikeno T, Ohno H, Sasaki E, Komatsu T, Ueno T, Uchigashima M, Mikuni T, Tainaka K, Tahara S, Takeuchi S, Tahara T, Uchiyama M, Nagano T, Urano Y.
General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process.
Journal of the American Chemical Society, 144, 43, 2022
10.1021/jacs.2c06397: https://pubs.acs.org/doi/10.1021/jacs.2c06397
Original paper Akihiro Nakada, Takuma Maruyama, Mako Kamiya, Kenjiro Hanaoka, Yasuteru Urano.
Rapid visualization of deeply located tumors in vivo by intravenous administration of a γ-glutamyltranspeptidase-activated fluorescent probe.
Bioconjugate Chemistry, 33, 523-529, 2022
10.1021/acs.bioconjchem.2c00039: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00039
Original paper Kuriki Y, Yoshioka T, Kamiya M, Komatsu T, Takamaru H, Fujita K, Iwaki H, Nanjo A, Akagi Y, Takeshita K, Hino H, Hino R, Kojima R, Ueno T, Hanaoka K, Abe S, Saito Y, Nakajima J, Urano Y.
Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities.
Chemical Science, 13, 2022
10.1039/d1sc06889j: https://pubs.rsc.org/en/content/articlelanding/2022/SC/D1SC06889J
Original paper Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka, Tatsuya Higashi.
Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.
World Journal of Clinical Oncology, 13, 2022
10.5306/wjco.v13.i11.880: https://www.wjgnet.com/2218-4333/full/v13/i11/880
A01 Takaaki Akaike
Original paper Shieh M, Ni X, Xu S, Lindahl SP, Yang M, Matsunaga T, Flaumenhaft R, Akaike T, Xian M.
Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs.
Redox Biol., 56, 2022
10.1016/j.redox.2022.102433: https://doi.org/10.1016/j.redox.2022.102433
Original paper Kunikata H, Tawarayama H, Tsuda S, Akaike T, Nakazawa T.
Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides.
Sci. Rep., 12(1), 2022
10.1038/s41598-022-21677-4: https://www.nature.com/articles/s41598-022-21677-4
Original paper Anzai H, Shindo Y, Kohata Y, Hasegawa M, Takana H, Matsunaga T, Akaike T, Ohta M.
Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing.
Sci. Rep., 12(1), 2022
10.1038/s41598-022-18788-3: https://www.nature.com/articles/s41598-022-18788-3
Original paper 4Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol., 57, 2022
10.1016/j.redox.2022.102514: https://doi.org/10.1016/j.redox.2022.102514
Original paper Tsutsuki H, Zhang T, Yahiro K, Ono K, Fujiwara Y, Iyoda S, Wei FY, Monde K, Seto K, Ohnishi M, Oshiumi H, Akaike T, Sawa T.
Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection.
iScience, 25(4), 2022
10.1016/j.isci.2022.104050: https://doi.org/10.1016/j.isci.2022.104050
Original paper Kasamatsu S, Tsutsuki H, Ida T, Sawa T, Watanabe Y, Akaike T, Ihara H.
Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants.
Nitric Oxide, 120, 2022
10.1016/j.niox.2022.01.004: https://doi.org/10.1016/j.niox.2022.01.004
Original paper Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma YT, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M.
Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.
Sci. Signal., 15(716), 2022
10.1126/scisignal.abj0644: https://www.science.org/doi/10.1126/scisignal.abj0644
Original paper Kaneko K, Miyamoto Y, Ida T, Morita M, Yoshimura K, Nagasaki K, Toba K, Sugisaki R, Motohashi H, Akaike T, Chikazu D, Kamijo R.
8-Nitro-cGMP suppresses mineralization by mouse osteoblasts.
J. Clin. Biochem. Nutr., 71(3), 2022
10.3164/jcbn.21-129: https://www.jstage.jst.go.jp/article/jcbn/71/3/71_21-129/_article
Original paper Kurane T, Matsunaga T, Ida T, Sawada K, Nishimura A, Fukui M, Umemura M, Nakayama M, Ohara N, Matsumoto S, Akaike T, Matsuzaki G, Takaesu G.
GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
FASEB J., 36(1), 2022
10.1096/fj.202101074RR: https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202101074RR
Original paper Hayashi K, Asai S, Umezawa K, Kakizoe H, Miyachi H, Morita M, Akaike T, Kuno H, Komatsu S, Watanabe T, Kawahara T.
Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS-CoV-2 as assessed by a plaque assay.
J. Clin. Lab. Anal., 36(1), 2022
10.1002/jcla.24146: https://doi.org/10.1002/jcla.24146
Original paper Tawarayama H, Suzuki N, Inoue-Yanagimachi M, Himori N, Tsuda S, Sato K, Ida T, Akaike T, Kunikata H, Nakazawa T.
Glutathione trisulfide prevents lipopolysaccharide-induced inflammatory gene expression in retinal pigment epithelial cells.
Ocul. Immunol. Inflamm., 30(4), 2020
10.1080/09273948.2020.1833224: https://doi.org/10.1080/09273948.2020.1833224
Original paper Erdélyi K, Ditrói T, Johansson HJ, Czikora Á, Balog N, Silwal-Pandit L, Ida T, Olasz J, Hajdú D, Mátrai Z, Csuka O, Uchida K, Tóvári J, Engebraten O, Akaike T, Børresen Dale AL, Kásler M, Lehtiö J, Nagy P.
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation.
Proc. Natl. Acad. Sci. USA., 118(45), 2021
10.1073/pnas.2100050118: https://doi.org/10.1073/pnas.2100050118
Original paper Takata T, Jung M, Matsunaga T, Ida T, Morita M, Motohashi H, Shen X, Kevil CG, Fukuto JM, Akaike T.
Methods in sulfide and persulfide research.
Nitric Oxide, 116, 2021
10.1016/j.niox.2021.09.002: https://doi.org/10.1016/j.niox.2021.09.002
Original paper Komae S, Kasamatsu S, Uchida K, Ihara H.
Quantitative determination of 2-oxo-imidazole-containing dipeptides by high-performance liquid chromatography/tandem mass spectrometry.
Antioxidants (Basel), 11(12), 2021
10.3390/antiox11122401: https://doi.org/10.3390/antiox11122401
Original paper Balasubramanian R, Hori K, Shimizu T, Kasamatsu S, Okamura K, Tanaka K, Ihara H, Masuda S.
The sulfide-responsive SqrR/BigR homologous regulator YgaV of Escherichia coli controls expression of anaerobic respiratory genes and antibiotic tolerance.
Antioxidants (Basel), 11(12), 2022
10.3390/antiox11122359: https://doi.org/10.3390/antiox11122359
Original paper Komae S, Kasamatsu S, Ihara H.
2-Oxo-imidazole dipeptides in meat.
Biosci. Biotechnol. Biochem., 86(11), 2022
10.1093/bbb/zbac138: https://doi.org/10.1093/bbb/zbac138
Original paper Ueda Y, Zhao W, Ihara H, Imahori Y, Tsantili E, Wendakoon SK, Chambers A, Bai J.
Functional characteristics of aldehyde dehydrogenase and its involvement in aromatic volatile biosynthesis in postharvest banana ripening.
Foods., 11(3), 2022
10.3390/foods11030347: https://doi.org/10.3390/foods11030347
Review Sawa T, Akaike T.
What triggers inflammation in COVID-19?
elife, 11, 2022
10.7554/eLife.76231: https://doi.org/10.7554/eLife.76231
A02 Hozumi Motohashi
Original paper Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi.
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop.
Redox Biol., 65, 2023
https://doi.org/10.1016/j.redox.2023.102834
Original paper Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi.
Contribution of NRF2 to sulfur metabolism and mitochondrial activity.
Redox Biology., Volume 60, 2023
10.1016/j.redox.2023.102624: https://doi.org/10.1016/j.redox.2023.102624
Original paper Zhao M, Murakami S, Matsumaru D, Kawauchi T, Nabeshima YI, Motohashi H.
NRF2 Pathway Activation Attenuates Aging-Related Renal Phenotypes due to α-Klotho Deficiency.
J Biochem., 171(5), 2022
10.1093/jb/mvac014: https://doi.org/10.1093/jb/mvac014
Original paper Okazaki K, Anzawa H, Katsuoka F, Kinoshita K, Sekine H, Motohashi H.
CEBPB is Required for NRF2-Mediated Drug Resistance in NRF2-Activated Non-Small Cell Lung Cancer Cells.
J Biochem., 171(5), 2022
10.1093/jb/mvac013: https://doi.org/10.1093/jb/mvac013
Original paper Kitamura H, Oishi T, Murakami S, Yamada-Kato T, Okunishi I, Yamamoto M, Katori Y, Motohashi H.
Establishment of Neh2-Cre:tdTomato Reporter Mouse for Monitoring the Exposure History to Electorphilic Stress.
Free Radical Biol Med, 193(2), 2022
10.1016/j.freeradbiomed.2022.11.004: https://doi.org/10.1016/j.freeradbiomed.2022.11.004
Original paper Patel SD, Anand D, Motohashi H, Katsuoka F, Yamamoto M, Lachke SA.
Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects.
Front Cell Dev Biol., 10, 2022
10.3389/fcell.2022.981893: https://www.frontiersin.org/articles/10.3389/fcell.2022.981893/full
Original paper Sengoku T, Shiina M, Suzuki K, Hamada K, Sato K, Uchiyama A, Kobayashi S, Oguni A, Itaya H, Kasahara K, Moriwaki H, Watanabe C,
Honma T, Okada C, Baba S, Ohta T, Motohashi H, Yamamoto M, Ogata K.
Structural basis of transcription regulation by CNC family transcription factor, Nrf2.
Nucleic Acids Res., 50(21), 2022
10.1093/nar/gkac1102: https://doi.org/10.1093/nar/gkac1102
Review Matsumaru D, Motohashi H.
The KEAP1-NRF2 System in Healthy Aging and Longevity.
Antioxidants (Basel), 10(12), 2021
10.3390/antiox10121929: https://doi.org/10.3390/antiox10121929
Review Kitamura H, Takeda H, Motohashi H
Genetic, metabolic and immunological features of cancers with NRF2 addiction.
FEBS Lett, 596(16), 2022
10.1002/1873-3468.14458: https://doi.org/10.1002/1873-3468.14458
Original paper Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K.
Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Int J Mol Sci, 23(6), 2022
10.3390/ijms23063201: https://doi.org/10.3390/ijms23063201
Original paper Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K.
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Int J Mol Sci, 23(15), 2022
10.3390/ijms23158433: https://doi.org/10.3390/ijms23158433
Original paper Sehsah R, Wu W, Ichihara S, Hashimoto N, Zong C, Yamazaki K, Sato H, Itoh K, Yamamoto M, Elsayed AA, El-Bestar S, Kamel E, Ichihara G.
Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility.
Toxicol Lett, 370, 2022
10.1016/j.toxlet.2022.09.004: https://doi.org/10.1016/j.toxlet.2022.09.004
Original paper Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K.
Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment.
Curr Res Transl Med, 71, 2022
110.1016/j.retram.2022.103367: https://doi.org/10.1016/j.retram.2022.103367
Original paper Iwamura H, Mizuno K, Akamatsu S, Hatakeyama S, Tobisawa Y, Narita S, Narita T, Yamashita S, Kawamura S, Sakurai T, Fujita N, Kodama H, Noro D, Kakizaki I, Nakaji S, Itoh K, Tsuchiya N, Ito A, Habuchi T, Ohyama C, Yoneyama T.
Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases.
Cancer Sci, 113, 2022
10.1111/cas.15395: https://doi.org/10.1111/cas.15395
Review Hasegawa T, Kakuta M, Yamaguchi R, Sato N, Mikami T, Murashita K, Nakaji S, Itoh K, Imoto S.
Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.
Sci Rep, 12, 2022
10.1038/s41598-022-11730-7: https://www.nature.com/articles/s41598-022-11730-7
Review Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A.
Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.
J Hum Genet, 67, 2022
10.1038/s10038-022-01011-6: https://www.nature.com/articles/s10038-022-01011-6
A02 Fan-Yan Wei
A02 Yasuhiro Ishimaru
Original paper Sato K, Saito S, Endo K, Kono M, Kakei T, Taketa H, Kato M, Hamamoto S, Grenzi M, Costa A, Munemasa S, Murata Y, Ishimaru Y, Uozumi N.
Green tea catechins, (−)-Catechin Gallate, and (−)-Gallocatechin Gallate are potent inhibitors of ABA-induced stomatal closure.
Advanced Science, 9, 21, 2022
10.1002/advs.202201403: https://doi.org/10.1002/advs.202201403
Original paper Yamanashi T, Uchiyama T, Saito S, Higashi T, Ikeda H Kikunaga H, Yamagami M, Ishimaru Y, and Uozumi N.
Potassium transporter KUP9 participates in K+ distribution in roots and leaves under low K+ stress.
Stress Biology, volume 2, 52, 2022
10.1007/s44154-022-00074-x: https://doi.org/10.1007/s44154-022-00074-x
Original paper Yang G, Ishimaru Y, Hoshino S, Muraoka Y, Uozumi N, Ueda M.
12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation.
Scientific Reports, 12, 1, 2022
10.1002/advs.202201403: https://doi.org/10.1038/s41598-022-11414-2
A02 Tomohiro Sawa
Original paper Tsubasa Sakurai, Sachiko Kamakura, Junya Hayase, Akira Kohda, Masafumi Nakamura, Hideki Sumimoto.
GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity.
J. Biol. Chem., 298, 2022
10.1016/j.jbc.2022.102475: https://doi.org/10.1016/j.jbc.2022.102475
Original paper Vlad Tocan, Junya Hayase, Sachiko Kamakura, Akira Kohda, Shouichi Ohga, Motoyuki Kohjima, Hideki Sumimoto.
Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl.
J. Biol. Chem., 297, 2021
10.1016/j.jbc.2021.101354: https://doi.org/10.1016/j.jbc.2021.101354
Review Tomohiro Sawa, Tsuyoshi Takata, Tetsuro Matsunaga, Hideshi Ihara, Hozumi Motohashi, and Takaaki Akaike.
Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of Polysulfides as a Determinant of Physiological Functions.
Antioxid Redox Signal, 36, 2022
10.1089/ars.2021.0170: https://doi.org/10.1089/ars.2021.0170
Review Tianli Zhang, Hiroyasu Tsutsuki, Xiaoyan Li, Tomohiro Sawa.
New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses.
J. Biochem., 171, 2022
10.1093/jb/mvab158: https://doi.org/10.1093/jb/mvab158
Review Sumimoto H, Kohda A, Hayase J, and Kamakura S.
The NADPH oxidase activator p67phox and its related proteins.
NADPH Oxidases Revisited: From Function to Structure, Pick, E., ed. (Berlin, Springer Nature), 2023
https://www.kinokuniya.co.jp/f/dsg-02-9783031237515
A02 Ryo Ushioda
Original paper Kaiku Uegaki, Yuji Tokunaga, Michio Inoue, Seiji Takashima, Kenji Inaba, Koh Takeuchi, Ryo Ushioda*, Kazuhiro Nagata* (*Corresponding author)
The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER.
Cell Rep., 42(7), 2023
https://doi.org/10.1016/j.celrep.2023.112742
press release： https://www.kyoto-su.ac.jp/news/2023_ls/20230725_400a_ronbun.html
Original paper Shohei Fujii, Ryo Ushioda and Kazuhiro Nagata.
Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors.
Proc Natl Acad Sci U S A. 2023 May 30;120(22)
10.1038/s41598-022-11342-1: https://doi.org/10.1073/pnas.2216857120
press release： https://www.kyoto-su.ac.jp/news/2023_ls/20230524_400a_ronbun.html
Original paper Hiroki Tanemura, Kenji Masuda, Takeshi Okumura, Eri Takagi, Daisuke Kajihara, Hirofumi Kakihara, Koichi Nonaka, Ryo Ushioda.
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells.
Scientific Reports, 12(1), 2022
10.1038/s41598-022-11342-1: https://www.nature.com/articles/s41598-022-11342-1
Original paper Riyuji Yamashita, Shohei Fujii, Ryo Ushioda, Kazuhiro Nagata.
Ca2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation.
Scientific Reports, 11(1), 2021
10.1038/s41598-021-99980-9: https://www.nature.com/articles/s41598-021-99980-9
A03 Motohiro Nishida
Original paper Kato Y, Nishiyama K, Lee JM, Ibuki Y, Imai Y, Noda T, Kamiya N, Kusakabe T, Kanda Y, Nishida M*.
TRPC3-Nox2 protein complex formation increases the risk of SARS-CoV-2 Spike protein-induced cardiomyocyte dysfunction through ACE2 upregulation.
Int. J. Mol. Sci. accepted, 2022
10.3390/ijms24010102: https://doi.org/10.3390/ijms24010102
Original paper Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M.
Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-34194-9: https://www.nature.com/articles/s41467-022-34194-9
Original paper Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species induced stress.
Redox Biology, 57, 2022
10.1016/j.redox.2022.102514: https://www.sciencedirect.com/science/article/pii/S2213231722002865?via%3Dihub
Original paper Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J,
Birnbaumer L, Mori Y, Nishida M.
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
British Journal of Pharmacology, 180, 1, 2022
10.1111/bph.15942: https://doi.org/10.1111/bph.15942
Original paper Shimauchi T, Numaga‐tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim S.G, Urano Y, Ohshima T, Nishida M.
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind‐Limb Ischemia.
Cells, 11, 13, 2022
10.3390/cells11132041: https://doi.org/10.3390/cells11132041
Original paper Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma Y.-T, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M.
Redox-dependent internalization ofthe purinergic P2Y6 receptor limits colitis progression.
Science Signaling, 15, 716, 2022
10.1126/scisignal.abj0644: https://www.science.org/doi/10.1126/scisignal.abj0644
Original paper Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A,
Hirai H, Ishido S, Yoshizawa T, Shindo T, Takada S, Kinugawa S, Inatome R, Yanagi S.
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.
iScience, 25, 7, 2022
10.1016/j.isci.2022.104582: https://doi.org/10.1016/j.isci.2022.104582
Original paper Yamada S, Noda T, Okabe K, Yanagida S, Nishida M, Kanda Y.
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium.
Journal of Pharmacological Sciences, 149, 3, 2022
10.1016/j.jphs.2022.04.010: https://doi.org/10.1016/j.jphs.2022.04.010
Original paper Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sat, K, Toyama T, Yamamura Y, Miyagawa T, Yamazaki H, Hara A, Shimizu M, Furuich, K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T.
Protective effect of D-alanine against acute kidney injury.
American Journal of Physiology - Renal Physiology, 322, 6, 2022
10.1152/ajprenal.00198.2021: https://doi.org/10.1152/ajprenal.00198.2021
Original paper Murata R, Watanabe H, Nosaki H, Nishida K, Maeda H, Nishida M, Maruyama T.
Long-Acting Thioredoxin Ameliorates Doxorubicin-Induced Cardiomyopathy via Its Anti-Oxidative and Anti-Inflammatory Action.
Pharmaceutics, 14, 3, 2022
10.3390/pharmaceutics14030562: https://doi.org/10.3390/pharmaceutics14030562
Original paper Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, Kanda Y.
Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.
International Journal of Molecular Sciences, 23, 4, 2022
10.3390/ijms23041967: https://doi.org/10.3390/ijms23041967
Original paper Masuda A, Lee J.M, Miyata T, Mon H, Sato K, Oyama K, Sakurai Y, Yasuda J, Takahashi D, Ueda T, Kato Y, Nishida M, Karasaki N, Kakino K, Ebihara T, Nagasato T, Hino M, Nakashima A, Suzuki K, Tonooka Y, Tanaka M, Moriyama T, Nakatake H, Fujita R, Kusakabe T.
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants.
Frontiers in Immunology, 12, 2022
10.3389/fimmu.2021.803647: https://doi.org/10.3389/fimmu.2021.803647
Original paper Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada K.-I.
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques.
Nature Communications, 12, 1, 2021
10.1038/s41467-021-26633-w: https://www.nature.com/articles/s41467-021-26633-w
Original paper Marutani E, Morita M, Hirai S, Kai S, Grange R.M.H, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker D.R,
Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin D.N, Ihara H, Olenchock B.A, Shen X, Nishida M, Hanaoka K, Kevil C.G, Xian M, Bloch D.B, Akaike T, Hindle A.G, Motohashi H, Ichinose F.
Sulfide catabolism ameliorates hypoxic brain injury.
Nature Communications, 12, 1, 2021
10.1038/s41467-021-23363-x: https://www.nature.com/articles/s41467-021-23363-x
Review Kato Y, Nishiyama K, Nishimura A, Noda T, Okabe K, Kusakabe T, Kanda Y, Nishida M.
Drug repurposing for the treatment of COVID-19.
Journal of Pharmacological Sciences, 149, 3, 2021
10.1016/j.jphs.2022.04.007: https://www.sciencedirect.com/science/article/pii/S1347861322000342
Review Nishimura A, Tanaka T, Kato Y, Nishiyama K, Nishida M.
Cardiac robustness regulated by reactive sulfur species.
Journal of Clinical Biochemistry and Nutrition, 70, 1, 2021
10.3164/JCBN.21-84: https://doi.org/10.3164/jcbn.21-84
A03 Shinji Masuda
Original paper Tomo Kondo, Takayuki Shimizu.
Translation Enhancement by a Short Nucleotide Insertion at 5′UTR: Application to an In Vitro Cell-Free System and a Photosynthetic Bacterium.
Appl. Microbiol., 3(3), 2023
10.3390/applmicrobiol3030047: https://doi.org/10.3390/applmicrobiol3030047
Original paper Takayuki Shimizu, Tomoaki Ida, Giuliano T Antelo, Yuta Ihara, Joseph N Fakhoury, Shinji Masuda, David P Giedroc, Takaaki Akaike, Daiana A Capdevila, Tatsuru Masuda.
Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics.
PNAS Nexus, 2(3), 2023
10.1093/pnasnexus/pgad048: https://doi.org/10.1093/pnasnexus/pgad048
Original paper Takayuki Shimizu, Masaru Hashimoto, Tatsuru Masuda.
Thioredoxin-2 Regulates SqrR-Mediated Polysulfide-Responsive Transcription via Reduction of a Polysulfide Link in SqrR.
Antioxidants, 12(3), 2023
10.3390/antiox12030699: https://doi.org/10.3390/antiox12030699
Original paper Balasubramanian R, Hori K, Shimizu T, Kasamatsu S, Okamura K, Tanaka K, Ihara H, Masuda S.
The sulfide-responsive SqrR/BigR homologous regulator YgaV of Escherichia coli controls expression of anaerobic respiratory genes and antibiotic tolerance.
Antioxidants, 11, 12, 2022
10.3390/antiox11122359: https://doi.org/10.3390/antiox11122359
Original paper Shimizu T, Aritoshi T, Beatty J.T and Masuda T.
Persulfide-responsive transcription factor SqrR regulates gene transfer and biofilm formation via the metabolic modulation of cyclic di-GMP in Rhodobacter capsulatus.
Microorganisms, 10, 5, 2022
10.3390/microorganisms10050908: https://doi.org/10.3390/microorganisms10050908
Original paper Ito K, Ito D, Goto M, Suzuki S, Masuda S, Iba K and Kusumi K.
Regulation of ppGpp Synthesis and Its Impact on Chloroplast Biogenesis during Early Leaf Development in Rice.
Plant and Cell Physiology, 63, 7, 2022
10.3389/fpls.2022.919896: https://link.springer.com/article/10.1007/s00425-022-03835-0
Original paper Goto M, Oikawa A, Masuda S.
Metabolic changes contributing to large biomass production in the Arabidopsis ppGpp-accumulating mutant under nitrogen deficiency.
Planta, 255, 2, 2022
10.1007/s00425-022-03835-0: https://doi.org/10.1093/pcp/pcac053
Original paper Trinh M.D.L, Hashimoto A, Kano M, Takaichi S, Nakahira Y and Masuda S.
Lack of plastid-encoded Ycf10, a homolog of the nuclear-encoded DLDG1 and the cyanobacterial PxcA, enhances the induction of non-photochemical quenching in tobacco.
Plant Direct, 5, 12, 2021
10.1002/pld3.368: https://doi.org/10.1002/pld3.368
Original paper Fujisawa T, Masuda S, Takeuchi S and Tahara T.
Femtosecond time-resolved absorption study of signaling state of a BLUF protein PixD from cyanobacterium Synechocystis: hydrogen bond rearrangement completes during forward proton-coupled electron transfer.
Journal of Physical Chemistry B, 125, 44, 2021
10.1021/acs.jpcb.1c05957: https://doi.org/10.1021/acs.jpcb.1c05957
Review Trinh M.D.L and Masuda S.
Chloroplast pH homeostasis for the regulation of photosynthesis.
Front. Plant Sci.B, 13, 2022
10.3389/fpls.2022.919896: https://www.frontiersin.org/articles/10.3389/fpls.2022.919896/full
A03 Yoshiro Saito
Original paper Takayuki Kaneko, Yuichiro Mita, Kanako Nozawa-Kumada, Masana Yazaki, Mieko Arisawa, Etsuo Niki, Noriko Noguchi, Yoshiro Saito.
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation.
Free Radical Research, 56 (9-10), 2023
10.1080/10715762.2023.2165918: https://doi.org/10.1080/10715762.2023.2165918
Original paper Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi.
A non-nucleotide agonist that binds covalently to cysteine residues of STING.
Cell Structure and Function, 48, 2022
10.1247/csf.22085: https://doi.org/10.1247/csf.22085
Original paper Yumie Takeshita, Takeo Tanaka, Hiroaki Takayama, Yuki Kita, Hisanori Goto, Yujiro Nakano, Yoshiro Saito, Toshinari Takamura.
Circulating selenoprotein P levels predict glucose-lowering and insulinotropic effects of metformin, but not alogliptin: A post-hoc analysis.
Journal of Diabetes Investigation, 14, 2022
10.1111/jdi.13949: https://doi.org/10.1111/jdi.13949
Original paper Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, and Spencer A. Freeman.
Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis.
Current Biology, in press, 2022
10.1101/2022.10.31.514557: https://doi.org/10.1101/2022.10.31.514557
Original paper Swe Mar Oo, Hein Ko Oo, Hiroaki Takayama, Kiyo-aki Ishii, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Susumu Kohno, Chiaki Takahashi, Hiroyuki Nakamura, Yoshiro Saito, Mami Matsushita, Yuko Okamatsu-Ogura, Masayuki Saito, and Toshinari Takamura.
Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
Cell Reports, 38, 110566, 2022
10.1016/j.celrep.2022.110566: https://doi.org/10.21203/rs.3.rs-155060/v1
Original paper Machiko Honda, Tatsuya Segawa, Kiyoshi Ishikawa, Masahiro Maeda, Yoshiro Saito, and Shigeyuki Kon.
Nephronectin influences EAE development by regulating Th17/Treg balance via reactive oxygen species.
American Journal of Physiology-Cell Physiology, 322(4), 2022
10.1152/ajpcell.00376.2021: https://doi.org/10.1152/ajpcell.00376.2021
Original paper Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, Takashi Toyama, Kiyo-aki Ishii, Toshinari Takamura, Noriko Noguchi, and Yoshiro Saito.
Role of selenoprotein P expression in the function of pancreatic beta cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
Free Radical Biology & Medicine, 183, 2022
10.1016/j.freeradbiomed.2022.03.009: https://doi.org/10.1016/j.freeradbiomed.2022.03.009
Original paper Daichi Chida, Takashi Toyama, Takanori Chiba, Takayuki Kaneko, Kotoko Arisawa and Yoshiro Saito.
Effects of the interplay between selenocystine and methylmercury on their cytotoxicity and glucose-driven insulin secretion from mouse insulinoma cells.
BPB Reports, 5, 2022
10.1248/bpbreports.5.4_74: https://doi.org/10.1248/bpbreports.5.4_74
Original paper Teresa Urbano, Marco Vinceti, Jessica Mandrioli, Annalisa Chiari,Tommaso Filippini, Roberta Bedin, Manuela Tondelli, Cecilia Simonini, Giovanna Zamboni, Misaki Shimizu, and Yoshiro Saito.
Selenoprotein P concentrations in cerebrospinal fluid and serum of individuals affected by amyotrophic lateral sclerosis, mild cognitive impairment and Alzheimer’s dementia.
International Journal of Molecular Sciences, 23, 2022
10.3390/ijms23179865: https://doi.org/10.3390/ijms23179865
Review Takashi Toyama, Takayuki Kaneko, Kotoko Arisawa, Yoshiro Saito.
Metal-binding properties of selenoprotein P—its relation to structure and function.
Metallomics Research, 2(3), p. rev-18-rev-27, 2022
10.11299/metallomicsresearch.MR202209: https://doi.org/10.11299/metallomicsresearch.MR202209
Review Yoshiro Saito.
Essential trace element selenium and redox regulation- its metabolism, physiological function, and related diseases.
Redox Experimental Medicine, 1, 2022
10.1530/REM-22-0010: https://doi.org/10.1530/REM-22-0010
Review Marco Vinceti, Tommaso Filippini, Ewa Jablonska, Yoshiro Saito, Lauren A. Wise.
Safety of selenium exposure and limitations of selenoprotein maximization: molecular and epidemiologic perspectives.
Environmental Research, 211, 113092, 2022
10.1016/j.envres.2022.113092: https://doi.org/10.1016/j.envres.2022.113092
Review Biplab Kumar Dash, Yasuomi Urano, Yoshiro Saito and Noriko Noguchi.
Redox-sensitive DJ-1 protein: an insight into physiological roles, secretion, and therapeutic target.
Redox Experimental Medicine, 1, R96–R115, 2022
10.1530/REM-22-0007: https://doi.org/10.1530/REM-22-0007
A03 Hiroaki Miki
Original paper Lohani S, Funato Y, Akieda Y, Mizutani K, Takai Y, Ishitani T, and Miki H.
A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence.
J. Cell Sci., 2022
10.1242/jcs.258550: https://doi.org/10.1242/jcs.258550
Original paper Ryu K, Yoshida A, Funato Y, Yamazaki D, and Miki H.
PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis.
Cell Struct. Funct., 47, 2022
10.1247/csf.22034: https://doi.org/10.1247/csf.22034
Review Funato Y, Hashizume O, and Miki H.
Phosphatase-independent role of phosphatase of regenerating liver in cancer progression.
Cancer Sci., 114, 25-33 (2023), 2022
10.1111/cas.15625: https://doi.org/10.1111/cas.15625
Review Funato Y and Miki H.
The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters.
J. Pharmacol. Sci., 148, 2022
10.1016/j.jphs.2021.09.004: https://doi.org/10.1016/j.jphs.2021.09.004
A01 Yasuhiro Shinkai
A01 Yuji Tokunaga
A01 CATTI LORENZO
A01 Kazuma Murakami
Original paper Morishita Y, Tsukada K, Murakami K, Irie K, Asai T.
Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.
Journal of Natural Products, 85, 2, 2022
10.1021/acs.jnatprod.1c00973: https://doi.org/10.1021/acs.jnatprod.1c00973
Original paper Hanaki M, Murakami K, Gunji H, Irie K.
Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis.
Bioorganic and Medicinal Chemistry Letters, 61, 2022
10.1016/j.bmcl.2022.128613: https://doi.org/10.1016/j.bmcl.2022.128613
Original paper Murakami K, Sakaguchi Y, Taniwa K, Izuo N, Hanaki M, Kawase T, Hirose K, Shimizu T, Irie K.
Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.
RSC Chemical Biology, 120, 2022
10.1039/d2cb00194b: https://doi.org/10.1039/D2CB00194B
Review Murakami K, Izuo N, Bitan G.
Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.
Journal of Biological Chemistry, 298, 1, 2022
10.1016/j.jbc.2021.101478: https://doi.org/10.1016/j.jbc.2021.101478
Review Murakami K, Ono K.
Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration.
FASEB Journal, 36, 9, 2022
10.1096/fj.202200235R: https://doi.org/10.1096/fj.202200235R
A01 Kazuya Matsuo
A01 Tsubasa Inokuma
Original paper Inokuma T, Masui K, Fukuhara K, Yamada K.-I.
Preparation of N-2-Nitrophenylsulfenyl Imino Peptides and Their Catalyst-Controlled Diastereoselective Indolylation.
Chemistry - A European Journal, 2022
10.1002/chem.202203120: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203120
Original paper Yamada K.-I, Yamauchi A, Fujiwara T, Hashimoto, Wang Y, Kuwano S, Inokuma T.
Kinetic Resolution of α-Hydroxyamide via N-Heterocyclic Carbene-Catalyzed Acylation.
Asian J. Organic Chemistry, 11(10), 2022
10.1021/acscatal.2c01579: https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202200452
Original paper Wang Y, Yamauchi A, Hashimoto K, Fujiwara T, Inokuma T, Mitani Y, Ute K, Kuwano S, Yamaoka Y, Takasu K, Yamada K.
Enhanced Molecular Recognition through Substrate−Additive Complex Formation in N‑Heterocyclic-Carbene-Catalyzed Kinetic Resolution of α‑Hydroxythioamides.
ACS Catal., 12, 10, 2022
10.1002/chem.202203120: https://pubs.acs.org/doi/10.1021/acscatal.2c01579
A02 Kenichi Yamada
Original paper Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Sci Signal, 15(758), 2022
10.1126/scisignal.abn8017: https://doi.org/10.1126/scisignal.abn8017
Original paper Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity.
J Cardiovasc Pharmacol., 80(5), 2022
10.1097/FJC.0000000000001328: https://journals.lww.com/cardiovascularpharm/Fulltext/2022/11000/Ethoxyquin_is_a_Competent_Radical_Trapping.9.aspx
Original paper Mishima E, Ito J, Wu Z, Nakamura, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada K.-I, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão A.S.D, Linkermann A, Geissler E.K, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt D.A, Conrad M.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Nature, 608(7924), 2022
10.1038/s41586-022-05022-3: https://www.nature.com/articles/s41586-022-05022-3
Original paper Yamauchi K, Matsuoka Y, Takahashi M, Izumi Y, Naka H, Taniguchi Y, Kawai K, Bamba T, Yamada K.-I.
Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe.
Chemical Communications, 58, 1, 2022
10.1039/d1cc04998d: https://doi.org/10.1039/D1CC04998D
Original paper Miyamoto H.D, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
JACC: Basic to Translational Science, 7, 8, 2022
10.1016/j.jacbts.2022.03.012: https://www.jacc.org/doi/abs/10.1016/j.jacbts.2022.03.012
Original paper Lerksaipheng P, Paiboonsukwong, Sanvarinda P, Leuchapudiporn R, Yamada K.-I, Morales N.P.
Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol.
Biomedicine and Pharmacotherapy, 154, 2022
10.1016/j.biopha.2022.113624: https://doi.org/10.1016/j.biopha.2022.113624
Original paper Kenichi Yamada
A02 Isshin Shiiba
A02 Tomoko Koumura
Original paper Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto H.D, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Science Signaling, 15, 758, 2022
10.1126/scisignal.abn8017: https://www.science.org/doi/10.1126/scisignal.abn8017
Original paper Miyamoto H.D, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
JACC: Basic to Translational Science, 7, 8, 2022
10.1016/j.jacbts.2022.03.012: https://www.jacc.org/doi/abs/10.1016/j.jacbts.2022.03.012
Original paper Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto H.D, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity.
Journal of Cardiovascular Pharmacology, 80, 5, 2022
10.1097/FJC.0000000000001328: https://journals.lww.com/cardiovascularpharm/Fulltext/2022/11000/Ethoxyquin_is_a_Competent_Radical_Trapping.9.aspx
Original paper Azuma K, Koumura T, Iwamoto R, Matsuoka M, Terauchi R, Yasuda S, Shiraya T, Watanabe S, Aihara M, Imai H, Ueta T.
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
Journal of Biological Chemistry, 298, 4, 2022
10.1016/j.jbc.2022.101824: https://doi.org/10.1016/j.jbc.2022.101824
A03 Makoto Kobayashi
Original paper Saida K, Tamaoki J, Sasaki M, Haniffa M, Koshimizu E, Sengoku T, Maeda H, Kikuchi M, Yokoyama H, Sakamoto M, Iwama K, Sekiguchi F, Hamanaka K, Fujita A, Miyatake S, Mizuguchi T, Ogata K, Miyake N, Kobayashi M and Matsumoto N.
Pathogenic variants in the SMN complex gene GEMIN5 cause cerebellar atrophy.
Clin. Genet., 100(6), 722-730, 2021
10.1111/cge.14066: https://onlinelibrary.wiley.com/doi/10.1111/cge.14066
Original paper Lichtenegger A, Mukherjee P, Tamaoki J, Bian L, Zhu L, El-Sadek I.A, Makita S, Leskovar K, Kobayashi M. Baumann B and Yasuno Y.
Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography.
J. Biomed., Opt.27(1), 2022
10.1117/1.JBO.27.1.016001: https://doi.org/10.1117/1.JBO.27.1.016001
Original paper Watanabe A, Muraki K, Tamaoki J and Kobayashi M.
Soy-derived equol induces antioxidant activity in zebrafish in an Nrf2-independent manner.
Int. J. Mol. Sci., 23(9), 2022
10.3390/ijms23095243: https://doi.org/10.3390/ijms23095243
Original paper Lichtenegger A, Tamaoki J, Licandro R, Mori T, Mukherjee1 P, Bian L, Greutter L, Makita S, Wöhrer A, Matsusaka S, Kobayashi M,
Baumann B and Yasuno Y.
Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography.
Scientific Reports, 12, 2022
10.1038/s41598-022-19483-z: https://www.nature.com/articles/s41598-022-19483-z
A03 Futoshi Okada
Original paper Ueno S, Kokura K, Kuromi Y, Osaki M, Okada F, Kitamura S, Ohbayashi T.
Kidney organoid derived from renal tissue stem cells is a useful tool for histopathological assessment of nephrotoxicity in a cisplatin-induced acute renal tubular injury model.
Journal of Toxicologic Pathology, 35, 4, 2022
10.1293/tox.2022-0006: https://doi.org/10.1293/tox.2022-0006
Original paper Izutsu R, Osaki M, Jehung J.P, Seong H.K, Okada F.
Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
Pathology Research and Practice, 237, 2022
10.1016/j.prp.2022.154015: https://pubmed.ncbi.nlm.nih.gov/35843033/
Original paper Goto K, Morimoto M, Osaki M, Tanio A, Izutsu R, Fujiwara Y, Okada F.
The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
BMC Cancer, 22, 1, 2022
10.1186/s12885-022-09339-0: https://pubmed.ncbi.nlm.nih.gov/35296279/
Original paper Izutsu R, Osaki M, Nemoto H, Jingu M, Sasaki R, Yoshioka Y, Ochiya T, Okada F.
AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
Scientific Reports, 12, 1, 2022
10.1038/s41598-021-04662-1: https://www.nature.com/articles/s41598-021-04662-1
Original paper Goto K, Osaki M, Izutsu R, Tanaka H, Sasaki R, Tanio A, Satofuka H, Kazuki Y, Yamamoto M, Kugoh H, Ito H, Oshimura M, Fujiwara Y,
Okada F.
Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer.
Diagnostic Pathology, 17, 1, 2022
10.1186/s13000-021-01176-2: https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-021-01176-2
Original paper Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F.
MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis.
Molecular Medicine Reports, 25, 1, 2022
10.3892/mmr.2021.12527: https://doi.org/10.3892/mmr.2021.12527
Original paper Nemoto H, Otake M, Matsumoto T, Izutsu R, Jehung J.P, Goto K, Osaki M, Mayama M, Shikanai M, Kobayashi H, Watanabe T, Okada F.
Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA).
Journal of Functional Foods, 88, 2022
10.1016/j.jff.2021.104907: https://doi.org/10.1016/j.jff.2021.104907
Original paper Hoshino Y, Sugihara T, Ikeda S, Tarumoto R, Matsuki Y, Kanda T, Iyama T, Takata T, Matono T, Nagahara T, Okano J.-I, Ueki M, Koda M,
Osaki M, Okada F, Isomoto H.
Newly Invented Micellized Vitamin K2 Recovered Prolonged Prothrombin Time under Obstructive Jaundice in Rats with Bile Duct Ligation.
Journal of Nutritional Science and Vitaminology, 67, 6, 2021
10.3177/JNSV.67.397: https://doi.org/10.3177/jnsv.67.397
A03 Akira Kawanabe
Original paper Takunari Kiya, Kohei Takeshita, Akira Kawanabe, and Yuichiro Fujiwara.
Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA.
J. Biol. Chem., Vol. 298(8), 102257, 2022
10.1016/j.jbc.2022.102257: https://doi.org/10.1016/j.jbc.2022.102257
A03 Akiko Maruyama
Original paper Y Iwamoto, S Saito, T Teramoto, A Maruyama-Nakashita, Y Kakuta.
Crystal structure of Arabidopsis thaliana sulfotransferase SOT16 involved in glucosinolate biosynthesis.
BBRC 677: 149-157, 2023
https://doi.org/10.1016/j.bbrc.2023.08.020
Original paper L Zhang, R Kawaguchi, T Enomoto, S Nishida, M Burow, A Maruyama-Nakashita.
Glucosinolate catabolism maintains glucosinolate profiles and transport in sulfur-starved Arabidopsis.
Plant Cell Physiol. 64: in press, 2023
https://doi.org/10.1093/pcp/pcad075
Original paper M Yasuda, M Fujita, K Soudthedlath, M Kusajima, H Takahashi, T Tanaka, F Narita, T Asami, A Maruyama-Nakashita, H Nakashita.
Characterization of disease resistance induced by a pyrazolecarboxylic acid derivative in Arabidopsis thaliana.
Int. J. Mol. Sci. 24: 9037, 2023
https://doi.org/10.3390/ijms24109037
Original paper J Piotrowska, Y Jodoi, N.H Trang, A Wawrzynska, H Takahashi, A Sirko, A Maruyama-Nakashita*.
The C-terminal region of SLIM1 transcription factor is required for sulfur deficiency response.
Plants, 11, 2022
10.3390/plants11192595: https://doi.org/10.3390/plants11192595
Original paper T Ito, T Kitaiwa, K Nishizono, M Umahashi, S Miyaji, S Agake, K Kuwahara, T Yokoyama, S Fushinobu, A Maruyama-Nakashita, R Sugiyama, M Sato, J Inaba, M.Y Hirai, N Ohkama-Ohtsu*.
Glutathione degradation activity of γ-Glutamyl Peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis.
Plant J, 111, 1626–1642, 2022
10.1111/tpj.15912: https://doi.org/10.1111/tpj.15912
Original paper M Kusajima, M Fujita, K Soudthedlath, H Nakamura, K Yoneyama, T Nomura, K Akiyama, A Maruyama-Nakashita, T Asami, H Nakashita*.
Strigolactones modulate salicylic acid-mediated disease resistance in Arabidopsis thaliana.
Int. J. Mol. Sci., 23, 2022
10.3390/ijms23095246: https://doi.org/10.3390/ijms23095246
Original paper H Li, A Suyama, N Mitani-Ueno, R Hell, A Maruyama-Nakashita*.
Low-level NaCl stimulates plant growth by improving carbon and sulfur assimilation in Arabidopsis thaliana.
Plants, 10, 2021
10.3390/plants10102138: https://doi.org/10.3390/plants10102138
A03 Masahiro Akiyama
Original paper Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biology, 57, 2022
10.1016/j.redox.2022.102514: https://doi.org/10.1016/j.redox.2022.102514
Original paper Masahiro Akiyama, Yasuhiro Shinkai, Hiroto Yamakawa, Yun-Gi Kim, Yoshito Kumagai.
Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome.
Chemosphere, 299, 2022
10.1016/j.chemosphere.2022.134374: https://doi.org/10.1016/j.chemosphere.2022.134374
Original paper Jun Uchiyama, Masahiro Akiyama, Koji Hase, Yoshito Kumagai, Yun-Gi Kim.
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species.
Cell reports, 38, 2022
10.1016/j.celrep.2022.110479: https://doi.org/10.1016/j.celrep.2022.110479
A03 Yuichiro Mita
B01 Atsushi Tahara
Original paper Tamer Shubair, Atsushi Tahara, Shahjalal Khandaker.
Optimizing the magnetic separation of strontium ion using modified zeolite with nano iron particles.
Case St. Chem. Env. Eng., 6, 2022
10.1016/j.cscee.2022.100243: https://doi.org/10.1016/j.cscee.2022.100243
Original paper Omar Falyouna, Khaoula Bensaida, Ibrahim Maamoun, U.P.M Ashik, Atsushi Tahara, Kazuya Tanaka, Noboru Aoyagi, Yuji Sugihara,
Osama Eljamal.
Synthesis of hybrid magnesium hydroxide/magnesium oxide nanorods [Mg(OH)2/MgO] for prompt and efficient adsorption of ciprofloxacin from aqueous solutions.
J. Clean. Prod., 342(15), 2022
10.1016/j.jclepro.2022.130949: https://doi.org/10.1016/j.jclepro.2022.130949
Original paper Takuya Kiyozumi, Shinji Kudo, Aska Mori, Riku Mizoguchi, Atsushi Tahara, Shusaku Asano, Jun-ichiro Hayashi.
Synthesis of Oxalate from CO2 and Cesium Carbonate Supported Over Porous Carbon.
ISIJ International, 62(12), 2022
10.2355/isijinternational.ISIJINT-2022-159: https://doi.org/10.2355/isijinternational.ISIJINT-2022-159
Original paper Shusaku Asano, Samuel J. Adams, Yuta Tsuji, Kazunari Yoshizawa, Atsushi Tahara,Jun-ichiro Hayashi.
Homogeneous catalyst modifier for alkyne semi-hydrogenation: systematic screening in an automated flow reactor and computational study on mechanisms.
React. Chem. Eng., 7, 2022
10.1039/D2RE00147K: https://doi.org/10.1039/D2RE00147K
B01 Tadachika Koganezawa
B01 Keisuke Wakasugi
B01 Ryoji Miyazaki
Original paper Ryoji Miyazaki, Mengting Ai, Natsuko Tanaka, Takehiro Suzuki, Naoshi Dhomae, Tomoya Tsukazaki, Yoshinori Akiyama,
Hiroyuki Mori.
Inner membrane YfgM–PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation.
J Biol Chem., 298(11), 2022
10.1016/j.jbc.2022.102572: https://doi.org/10.1016/j.jbc.2022.102572
B01 Isao Ishii
Original paper Manandhar, S. Chambers, S. Miller, A. Ishii, I. Bhatia, M.
Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells.
International journal of molecular sciences. 2023
24, https://www.mdpi.com/1422-0067/24/17/13650
Review Kamata, S. Honda, A. Ishii, I.
Current clinical trial status and future prospects of PPAR-targeted drugs for treating nonalcoholic fatty liver disease.
Biomolecules 2023
13, https://www.mdpi.com/2218-273X/13/8/1264
Original paper Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, Oyama T, Ishii I.
Functional and structural insights into the human PPARα/δ/γ targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor.
Antioxidants. 2023
12(8):1523 https://doi.org/10.3390/antiox12081523
Original paper Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, and Akaike T.
Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism.
Antioxidants. 2023
12(4):868: https://doi.org/10.3390/antiox12040868
Original paper Akahoshi N, Hasegawa R, Yamamoto S, Takemoto R, Yoshizawa T, Kamichatani W, Ishii I.
Differential roles of cystathionine gamma-lyase and mercaptopyruvate sulfurtransferase in hapten-induced colitis and contact dermatitis in mice.
Int. J. Mol. Sci. 2023
24(3):2659: https://doi.org/10.3390/ijms24032659
Original paper Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H.
Opposing roles of sphingosine 1-phosphate receptors 1 and 2 in fat deposition and glucose tolerance in obese male mice.
International Journal of Molecular Sciences, 23, 2, 2022
Endocrionology. 2023;
164(3):1716–1726: https://doi.org/10.1210/endocr/bqad019
Review Ishii I, Bhatia M.
Amino acids in health and disease: The good, the bad, and the ugly.
Int. J. Mol. Sci. 2023
24(5):4931: https://doi.org/10.3390/ijms24054931
Original paper Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N.
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
International Journal of Molecular Sciences, 23, 2, 2022
10.3390/ijms23020928: https://doi.org/10.3390/ijms23020928
Original paper Murae M, Shimizu Y, Yamamoto Y, Kobayashi A, Houri M, Inoue T, Irie T, Gemba R, Kondo Y, Nakano Y, Miyazaki S, Yamada D, Saitoh A,
Ishii I, Onodera T, Takahashi Y, Wakita T, Fukasawa M, Noguchi K.
The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione.
Biochemical and Biophysical Research Communications, 597, 2022
10.1016/j.bbrc.2022.01.106: https://doi.org/10.1016/j.bbrc.2022.01.106
Original paper Honda A, Kamata S, Akahane M, Machida Y, Uchii K, Shiiyama Y, Habu Y, Miyawaki S, Kaneko C, Oyama T, Ishii I.
Functional and Structural Insights into Human PPARα/δ/Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.
International Journal of Molecular Sciences, 23, 9, 2022
10.3390/ijms23094726: https://doi.org/10.3390/ijms23094726
Original paper Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, Narita S, Shibata R, Ishii I, Calvert JW, et al.
Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K/Akt-dependent mechanism.
J Am Heart Assoc, 11, 2022
10.1161/JAHA.122.026889: https://www.ahajournals.org/doi/10.1161/JAHA.122.026889
Review Kamata S, Ishii I.
PPARα-ligand binding modes revealed by X-ray crystallography.
Yakugaku zasshi, 141(11), 2021
10.1248/yakushi.21-00138: https://doi.org/10.1248/yakushi.21-00138
Review Honda A, Ishii I.
The perspective of PPAR dual/pan agonists as therapeutic drugs against NAFLD.
Yakugaku zasshi, 142(12), 2022
10.1248/yakushi.22-00159-1: https://doi.org/10.1248/yakushi.22-00159-1