A01　中川　秀彦

原著　Naoya Ieda, Masato Sawada, Runa Oguchi, Masato Itoh, Seina Hirakata, Daisuke Saitoh, Akito Nakao, Mitsuyasu Kawaguchi, Kazunobu Sawamoto, Toshitada Yoshihara, Yasuo Mori, and Hidehiko Nakagawa.
An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia.
Angew. Chem. Int. Ed, 62, e202217585, 2023
10.1002/anie.202217585: doi/10.1002/anie.202217585

原著　Ikeda-Imafuku M, Fukuta T, Tuan Giam Chuang V, Sawa T, Maruyama T, Otagiri M, Ishida T, Ishima Y.
Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.
Pharmaceuticals (Basel), 17(1): 128, 2024
10.3390/ph17010128 : https://www.mdpi.com/1424-8247/17/1/128

原著　Hirai T, Ikeda-Imafuku M, Tasaka N, Tuan Giam Chuang V, Xian M, Ishida T, Akaike T, Ishima Y.
Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides.
Adv. Redox Res, 10 :100091, 2024
10.1016/j.arres.2023.100091: https://www.sciencedirect.com/science/article/pii/S2667137923000310

原著　Xiaokang Tang, Akiyuki Nishimura, Kohei Ariyoshi, Kazuhiro Nishiyama, Yuri Kato, Elena A Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Jin Han, Yasunari Kanda, Keitaro Umezawa, Yasuteru Urano, Takaaki Akaike, Motohiro Nishida.
Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial infarction in mice.
Marine Drugs, 21(1), 52, 2023
10.3390/md21010052: https://www.mdpi.com/1660-3397/21/1/52/review_report

原著　Naoya Ieda, Yuka Yoshikawa, Natsumi Tomita, Kei Ohkubo, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, and Hidehiko Nakagawa.
Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation.
Chem. Commun., 58, 2022
10.1039/D2CC03193K: https://doi.org/10.1039/D2CC03193K

原著　Kan'ichiro Ishiuchi, Akiho Nagumo, Mitsuyasu Kawaguchi, Honoka Furuyashiki, Hidehiko Nakagawa, and Dai Hirose.
Stereochemistries of Mariannamides C and D, Two Lipohexapeptides, Isolated from Mariannaea elegans NBRC102301.
Heterocycles, 104, 2022
10.3987/COM-22-14728: https://www.heterocycles.jp/newlibrary/payments/form/27733/PDFwithLinks

原著　Keisuke Maeda, Makoto Habara, Mitsuyasu Kawaguchi, Hiroaki Matsumoto, Shunsuke Hanaki, Takahiro Masaki, Yuki Sato,
Hideyasu Matsuyama, Kazuki Kunieda, Hidehiko Nakagawa, and Midori Shimada.
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
Molecular Oncology, 16, 2022
10.1002/1878-0261.13030: https://doi.org/10.1002/1878-0261.13030

原著　Tachibana K, Kusumoto K, Ogawa M, Ando H, Shimizu T, Ishima Y, Ishida T, Okuhira K.
FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages.
Int J Mol Sci., 23(23), 2022
10.3390/ijms232314617: https://doi.org/10.3390/ijms232314617

原著　Ishima Y, Yamazaki N, Chuang VTG, Shimizu T, Ando H, Ishida T.
A Maleimide-Terminally Modified PEGylated Liposome Induced the Accelerated Blood Clearance Independent of the Production of Anti-PEG IgM Antibodies.
Biol Pharm Bull., 45(10), 2022
10.1248/bpb.b22-00389: https://doi.org/10.1248/bpb.b22-00389

原著　Beppu T, Nishi K, Imoto S, Araki W, Setoguchi I, Ueda A, Suetsugi N, Ishima Y, Ikeda T, Otagiri M, Yamasaki K.
Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts.
Oncol Rep., 48(4), 2022
10.3892/or.2022.8393: https://doi.org/10.3892/or.2022.8393

原著　Ando H, Ikeda A, Tagami M, Matsuo NCA, Shimizu T, Ishima Y, Eshima K, Ishida T.
Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil^® via neutralizing the acidic tumor microenvironment.
J Control Release., 350, 2022
10.1016/j.jconrel.2022.08.031: https://doi.org/10.1016/j.jconrel.2022.08.031

原著　Kawaguchi Y, Shimizu T, Ando H, Ishima Y, Ishida T.
Development of a Nanocarrier-Based Splenic B Cell-Targeting System for Loading Antigens in Vitro.
Biol Pharm Bull., 45(7), 2022
10.1248/bpb.b22-00222: https://doi.org/10.1248/bpb.b22-00222

原著　Tanaka Y, Okuyama H, Nishikawa M, Ikushiro SI, Ikeda M, Ishima Y, Ukawa Y, Oe K, Terao J, Mukai R.
8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells.
Food Sci Nutr., 10(4), 2022
10.1002/fsn3.2733: https://doi.org/10.1002/fsn3.2733

原著　Nishi K, Imoto S, Beppu T, Uchibori S, Yano A, Ishima YU, Ikeda T, Tsukigawa K, Otagiri M, Yamasaki K.
The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism.
Anticancer Res., 42(3), 2022
10.21873/anticanres.15601: https://ar.iiarjournals.org/content/42/3/1333

原著　El Sayed MM, Shimizu T, Abu Lila AS, Elsadek NE, Emam SE, Alaaeldin E, Kamal A, Sarhan HA, Ando H, Ishima Y, Ishida T.
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes.
Int J Pharm., 615, 2022
10.1016/j.ijpharm.2022.121539: https://doi.org/10.1016/j.ijpharm.2022.121539

原著　Nakajima T, Nagano K, Fukuda Y, Ishima Y, Shibata H, Isaka R, Zhang TQ, Haga Y, Higashisaka K, Tsujino H, Ishida T, Ishii-Watabe A, Tsutsumi Y.
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.
J Pharm Sci., 111(5), 2022
10.1016/j.xphs.2022.01.023: https://doi.org/10.1016/j.xphs.2022.01.023

原著　Mostafa M, Elsadek NE, Emam SE, Ando H, Shimizu T, Abdelkader H, Ishima Y, Aly UF, Sarhan HA, Ishida T.
Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation.
Biol Pharm Bull., 45(1), 2022
10.1248/bpb.b21-00772: https://doi.org/10.1248/bpb.b21-00772

原著　Ando-Matsuoka R, Ando H, Abu Lila AS, Maeda N, Shimizu T, Ishima Y, Ishida T.
I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors.
J Control Release., 341, 2022
10.1016/j.jconrel.2021.12.004: https://doi.org/10.1016/j.jconrel.2021.12.004

原著　Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T.
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH.
J Control Release., 341, 2022
10.1016/j.jconrel.2021.11.039: https://doi.org/10.1016/j.jconrel.2021.11.039

原著　Keitaro Umezawa, Hiroki Tsumoto, Kyojiro Kawakami, Yuri Miura.
A chemical probe for proteomic analysis and visualization of intracellular localization of lysine-succinylated proteins.
Analyst, 148, 2023
10.1039/D2AN01370C: https://pubs.rsc.org/en/content/articlelanding/2023/an/d2an01370c

総説　川口 充康、中嶋 雄哉、中川 秀彦
Sirtuin蛍光プローブの創製とそれを活用した論理的阻害剤開発および探索
有機合成化学協会誌, 80, 2022
10.5059/yukigoseikyokaishi.80.831: https://doi.org/10.5059/yukigoseikyokaishi.80.831

総説　Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T.
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.
J Control Release., 351, 2022
10.1016/j.jconrel.2022.09.031: https://doi.org/10.1016/j.jconrel.2022.09.031

総説　Matsuo NCA, Ando H, Doi Y, Shimizu T, Ishima Y, Ishida T.
The Challenge to Deliver Oxaliplatin (l-OHP) to Solid Tumors: Development of Liposomal l-OHP Formulations.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c22-00099: https://doi.org/10.1248/cpb.c22-00099

総説　Shimizu T, Kawaguchi Y, Ando H, Ishima Y, Ishida T.
Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c22-00047: https://doi.org/10.1248/cpb.c22-00047

総説　Ishima Y, Maruyama T, Otagiri M, Chuang VTG, Ishida T.
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors.
Chem Pharm Bull (Tokyo), 70(5), 2022
10.1248/cpb.c21-01024: https://doi.org/10.1248/cpb.c21-01024

A01　和田　啓

原著　Tatsuya Joutsuka, Ryota Nanasawa, Keisuke Igarashi, Kazuki Horie, Masakazu Sugishima, Yoshinori Hagiwara, Kei Wada, Keiichi Fukuyama, Naomine Yano, Seiji Mori, Andreas Ostermann, Katsuhiro Kusaka, and Masaki Unno.
Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states.
J. Biol. Chem., in press., 2022
10.1016/j.jbc.2022.102763: https://doi.org/10.1016/j.jbc.2022.102763

原著　Michiko Takahashi, Kei Wada, Syun-ichi Urayama, Yuichi Masuda, Keizo Nagasaki.
Degenerate PCR Targeting the Major Capsid Protein Gene of HcRNAV and Related Viruses.
Microbes and Environments, 37(5), ME21075, 2022
10.1264/jsme2.ME21075: https://doi.org/10.1264/jsme2.ME21075

原著　Ishizaka M, Chen M, Narai S, Tanaka Y, Ose T, Horitani M, and Yao M.
Rapid and spontaneous transformation between [3Fe–4S] and [4Fe–4S] iron–sulfur clusters in the tRNA-thiolation enzyme TtuA.
International Journal of Molecular Sciences. Accepted, 2022

原著　Hishinuma E, Narita Y, Rico E.G, Ueda A, Obuchi K, Tanaka Y, Saito S, Tadaka S, Kinoshita K, Maekawa M, Mano N, Nakayoshi T, Oda A, Hirasawa N, and Hiratsuka M.
Functional characterization of 12 dihydropyrimidinase allelic variants in Japanese individuals for the prediction of 5-fluorouracil treatment-related toxicity.
Drug Metabolism and Disposition. Accepted(2022), 51(2), 2023
10.1124/dmd.122.001045: https://dmd.aspetjournals.org/content/51/2/165

原著　Watari H, Kageyama H, Masubuchi N, Nakajima H, Onodera K, Focia P.J, Oshiro T, Matsui T, Kodera Y, Ogawa T, Yokoyama T, Hirayama M, Hori K, Freymann D.M, Imai M, Komatsu N, Araki M, Tanaka Y, Sakai R.
A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-34921-2: https://www.nature.com/articles/s41467-022-34921-2

原著　Kodama K, Rich M.K, Yoda A, Shimazaki S, Xie X, Akiyama K, Mizuno Y, Komatsu A, Luo Y, Suzuki H, Kameoka H, Libourel C, Keller J, Sakakibara K, Nishiyama T, Nakagawa T, Mashiguchi K, Uchida K, Yoneyama K, Tanaka Y, Yamaguchi S, Shimamura M, Delaux P.-M,
Nomura T, Kyozuka J.
An ancestral function of strigolactones as symbiotic rhizosphere signals.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-31708-3: https://www.nature.com/articles/s41467-022-31708-3

原著　Tsugita A, Uehara S, Matsui T, Yokoyama T, Ostash I, Deneka M, Yalamanchili S, Bennett C.S, Tanaka Y, Ostash B.
The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK.
FEBS Journal, 289, 19, 2022
10.1111/febs.16460: https://doi.org/10.1111/febs.16460

原著　Ghanem N, Kanagami N, Matsui T, Takeda K, Kaneko J, Shiraishi Y, Choe C.A, Uchikubo-Kamo T, Shirouzu M, Hashimoto T, Ogawa T, Matsuura T, Huang P.-S, Yokoyama T, Tanaka Y.
Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain.
FEBS Journal, 289, 12, 2022
10.1111/febs.16354: https://doi.org/10.1111/febs.16354

原著　Tagami T, Chen M, Furunaga Y, Kikuchi A, Sadahiro J, Lang W, Okuyama M, Tanaka Y, Iwasaki T, Yao M, and Kimura A.
Structural insights reveal the second base catalyst of isomaltose glucohydrolase.
The FEBS J., 289, 2022
10.1111/febs.16237: https://doi.org/10.1111/febs.16237

原著　和田 啓
細胞の酸化ストレス制御の構造生物学
日本結晶学会誌, 63, 2021
10.5940/jcrsj.63.105: https://doi.org/10.5940/jcrsj.63.105

A01　中林　孝和

原著　Keisuke Koga, Shinji Kajimoto, Yuta Yoshizaki, Hiroaki Takahashi, Lisa Kageyama, *Tomohiro Konno, *Takakazu Nakabayashi.
Establishment of a Method for the Introduction of Poorly Water-Soluble Drugs in Cells and Evaluation of Intracellular Concentration Distribution Using Resonance Raman Imaging.
Journal of Physical Chemistry , 128, 1350-1359, 2024
10.1021/acs.jpcb.3c06601

原著　Kazunori Ban, Daisuke Miyata, Yoshiteru Matsumoto, Shinya Tahara, Hiroaki Takahashi, Shin-ichi Morita, *Takakazu Nakabayashi.
Visualization of the sequence of changes in the full wavenumber range by two-dimensional correlation spectroscopy.
Chemical Physics Letters, 833, 140930, 2023
10.1016/j.cplett.2023.140930

原著　Kosuke Yamazaki, Shinya Tahara, Takumi Ohyama, Kunisato Kuroi, Takakazu Nakabayashi.
SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage.
Scientific Reports, 12, 1, 2022
10.1038/s41598-022-15701-w: https://www.nature.com/articles/s41598-022-15701-w

原著　Kohei Yokosawa, Shinji Kajimoto, Daiki Shibata, Kunisato Kuroi, Tomohiro Konno, Takakazu Nakabayashi.
Concentration Quantification of the Low-Complexity Domain of Fused in Sarcoma inside a Single Droplet and Effects of Solution Parameters.
Journal of Physical Chemistry Letters, 13, 24, 2022
10.1021/acs.jpclett.2c00962: https://doi.org/10.1021/acs.jpclett.2c00962

総説　中林 孝和、梶本 真司
ラマン顕微鏡で細胞内の水を見る
化学と工業, 2022
https://www.chemistry.or.jp/division-topics/2022/02/post-216.html

総説　​中林 孝和
蛍光寿命顕微鏡
先端の分析法 第2版（エヌ・ティー・エス）, 2022
http://www.stbook.co.jp/products/detail.php?product_id=613

総説　中林 孝和、柴田 大輝、高橋 大智、梶本 真司
ラマン顕微鏡を用いた生体分子密度変化，"ラマン顕微鏡を用いた細胞内の脂肪滴の直接観測"，"ラマン顕微鏡を用いた細胞内の温度観測"
ラマン分光スペクトル解析事例集（技術情報協会）, 2022
https://www.gijutu.co.jp/doc/b_2143.html

総説　中林 孝和、梶本 真司
ラマン分光による細胞の中の水の計測と分子夾雑環境・温度イメージングへの応用
光学, 51, 2022
http://myosj.or.jp/kogaku/backnumber/51-05/

総説　中林 孝和、梶本 真司
ラマンイメージングを用いた細胞内の水・夾雑環境の理解
生物工学会誌, 100, 2022
10.34565/seibutsukogaku.100.7_367: https://doi.org/10.34565/seibutsukogaku.100.7_367

総説　中林 孝和、黒井 邦巧、梶本 真司
ラマン顕微鏡によるラベルフリーなタンパク質液滴定量法
生化学, 94, 2022
10.14952/SEIKAGAKU.2022.940444: https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2022.940444/index.html

総説　梶本 真司、柴田 大輝、中林 孝和
ラマン顕微鏡による相分離の定量解析
実験医学別冊「相分離の解析プロトコール「それ本当に相分離」と言われないための戦略と先端解析方法」, 加藤 昌人、白木 賢太郎、中川 真一編, 2022
https://www.yodosha.co.jp/yodobook/book/9784758122597/

総説　影山 莉沙、中林 孝和
量子化学計算・ラマン分光法を用いた硫黄化合物の構造解析の動向
生化学, 93, 2021
10.14952/SEIKAGAKU.2021.930621: https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2021.930621/data/index.html

A01　花岡　健二郎

原著　Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano.
Development of Pathway-Oriented Screening to Identify Compounds to Control 2-Methylglyoxal Metabolism in Tumor Cells.
Commun. Chem, 6, 68, 2023
10.1038/s42004-023-00864-y: https://www.nature.com/articles/s42004-023-00864-y

原著　Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano.
Discovery of a Cystathionine γ-Lyase (CSE) Selective Inhibitor Targeting Active-site Pyridoxal 5’-Phosphate (PLP) via Schiff Base Formation.
Scientific Reports, 13, 1645, 2023
10.1038/s41598-023-43536-6: https://www.nature.com/articles/s41598-023-43536-6

原著　Tomohiro Sawa, Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike.
Alkyl Gallates Inhibit Serine O-Acetyltransferase in Bacteria and Enhance Susceptibility of Drug-Resistant Gram-Negative Bacteria to Antibiotics.
Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy, 14, 1276447, 2023
10.3389/fmicb.2023.1276447: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1276447/full

原著　Tatsuya Ukegawa, Toru Komatsu, Mayano Minoda, Takuya Matsumoto, Takumi Iwasaka, Tadahaya Mizuno, Ryo Tachibana, Shingo Sakamoto, Kenjiro Hanaoka, Hiroyuki Kusuhara, Kazufumi Honda, Rikiya Watanabe, Yasuteru Urano.
Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition.
Advanced Science, 2306559, 2023
10.1002/advs.202306559: https://onlinelibrary.wiley.com/doi/10.1002/advs.202306559

原著　Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Kazuya Maeda, Hiroyuki Kusuhara, Yasuteru Urano.
A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).
Science Advances, 10, eadi8847, 2024
10.1126/sciadv.adi8847: https://www.science.org/doi/full/10.1126/sciadv.adi8847

総説　Hisashi Ohno, Eita Sasaki, Sota Yamada, Kenjiro Hanaoka.
Recent advances in Si-rhodamine-based fluorescence probes for live-cell imaging.
Organic & Biomolecular Chemistry, 22, 3099-3108, 2024
10.1039/D4OB00130C: https://pubs.rsc.org/en/content/articlelanding/2024/ob/d4ob00130c

原著　Hoshino Y, Hanaoka K, Sakamoto K, Yasunaga M, Kojima T, Kotani D, Nomoto A, Sasaki E, Komatsu T, Ueno T, Takamaru H, Saito Y, Seto Y, Urano Y.
Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity.
RSC Chemical Biology, 3, 7, 2022
10.1039/d1cb00253h: https://pubs.rsc.org/en/content/articlelanding/2022/cb/d1cb00253h#fn1

原著　Hanaoka K, Iwaki S, Yagi K, Myochin T, Ikeno T, Ohno H, Sasaki E, Komatsu T, Ueno T, Uchigashima M, Mikuni T, Tainaka K, Tahara S, Takeuchi S, Tahara T, Uchiyama M, Nagano T, Urano Y.
General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process.
Journal of the American Chemical Society, 144, 43, 2022
10.1021/jacs.2c06397: https://pubs.acs.org/doi/10.1021/jacs.2c06397

原著　Akihiro Nakada, Takuma Maruyama, Mako Kamiya, Kenjiro Hanaoka, Yasuteru Urano.
Rapid visualization of deeply located tumors in vivo by intravenous administration of a γ-glutamyltranspeptidase-activated fluorescent probe.
Bioconjugate Chemistry, 33, 523-529, 2022
10.1021/acs.bioconjchem.2c00039: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00039

原著　Kuriki Y, Yoshioka T, Kamiya M, Komatsu T, Takamaru H, Fujita K, Iwaki H, Nanjo A, Akagi Y, Takeshita K, Hino H, Hino R, Kojima R, Ueno T, Hanaoka K, Abe S, Saito Y, Nakajima J, Urano Y.
Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities.
Chemical Science, 13, 2022
10.1039/d1sc06889j: https://pubs.rsc.org/en/content/articlelanding/2022/SC/D1SC06889J

原著　Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka, Tatsuya Higashi.
Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.
World Journal of Clinical Oncology, 13, 2022
10.5306/wjco.v13.i11.880: https://www.wjgnet.com/2218-4333/full/v13/i11/880

総説　花岡 健二郎
創薬研究のための蛍光プローブの分子設計と活用方法
MED CHEM NEWS, 32(2), 87-92, 2022
10.14894/medchem.32.2_87: https://doi.org/10.14894/medchem.32.2_87

総説　佐々木 栄太、花岡 健二郎
非ウイルス性タンパク質シェル工学の現在と将来展望
JSMI Report, 15(2), 11-16, 2022
http://www.molecularimaging.jp/journal2/journal_detail.asp?journal_id=4091

A01　赤池　孝章

原著　Eiki Kanemaru, Eizo Marutani, Masanobu Morita, Maria Miranda, Yusuke Miyazaki, Donald B. Bloch, Takaaki Akaike, Fumito Ichinose.
Exclusion of sulfide:quinone oxidoreductase from mitochondria causes Leigh-like disease in mice by impairing sulfide metabolism.
Journal of Clinical Investigation, Provisionally accepted, 2024

原著　Hiroaki Fujita, Yu-ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, and Kazuhiro Iwai.
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
Nature Structural Molecular Biology, in press, 2024

原著　Hiroki Sekine, Haruna Takeda, Norihiko Takeda, Akihiro Kishino, Hayato Anzawa, Takayuki Isagawa, Nao Ohta, Shouhei Murakami, Hideya Iwaki, Nobuhumi Kato, Shu Kimura, Liu Z, Koichiro Kato, Fumiki Katsuoka, Masayuki Yamamoto, Fumihito Miura, Takashi Ito, Masatomo Takahashi, Yoshihiro Izumi, Hiroyuki Fujita, Hitoshi Yamagata, Takeshi Bamba, Takaaki Akaike, Norio Suzuki, Kengo Kinoshita, Hozumi Motohashi.
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
Nature Metabolism, in press, 2024

原著　Jun Suzuki, Tomotaka Hemmi, Tomoaki Ida, Seiryo Ogata, Jun Yoshitake, Tetsuro Matsunaga, Tomoyasu Ishida, Yuki Numano, Yusuke Kusano, Ryoukichi Ikeda, Kazuhiro Nomura, Mitsuru Sugawara, Nobuo Ohta, Takaaki Akaike, Yukio Katori.
Supersulfide formation in the sinus mucosa of chronic rhinosinusitis.
Laryngoscope Investigative Otolaryngology , in press, 2024

原著　Qi Cui, Meg Shieh, Tony W. Pan, Akiyuki Nishimura, Tetsuro Matsunaga, Shane S. Kelly, Shi Xu, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Xiaoyan Chen, Jerome R. Robinson, Wei-Jun Qian, Motohiro Nishida, Takaaki Akaike, Ming Xian.
2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels.
Nature Communications, 15(1): 2453, 2024
10.1038/s41467-024-46652-7

原著　Sho Kakizawa, Tomoko Arasaki, Ayano Yoshida, Ayami Sato, Yuka Takino, Akihito Ishigami, Takaaki Akaike, Shuichi Yanai, Shogo Endo.
Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity.
Redox Biology, 70: 103053, 2024
10.1016/j.redox.2024.103053.

総説　Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa.
Regulation of innate immune and inflammatory responses by supersulfides.
International Immunology , 36(4): 143-154, 2024
10.1093/intimm/dxad057

原著　Akira Nishimura, Sunghyeon Yoon, Tetsuro Matsunaga, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Yuka Unno, Uladzimir Barayeu, Tsuyoshi Takata, Hiroshi Takagi, Hozumi Motohashi, Albert van der Vliet, Takaaki Akaike.
Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality.
Redox Biology, 69: 103018, 2024
10.1016/j.redox.2023.103018

原著　Shingo Kasamatsu, Ayaka Kinno, Chiharu Miura, Jun-Ichi Hishiyama, Kensuke Fukui, Shoji Kure, Kazunobu Tsumura, Tomoaki Ida, Tetsuro Matsunaga, Takaaki Akaike, Hideshi Ihara.
Quantitative profiling of supersulfides naturally occurring in dietary meats and beans.
Analytical Biochemistry, 685: 115392, 2023
10.1016/j.ab.2023.115392

原著　Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa.
Alkyl Gallates Inhibit Serine O-Acetyltransferase in Bacteria and Enhance Susceptibility of Drug-Resistant Gram-Negative Bacteria to Antibiotics.
Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy, 14, 1276447, 2023
10.3389/fmicb.2023.1276447: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1276447/full

原著　Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike.
Supersulfide biology and translational medicine for disease control.
British Journal of Pharmacology, in press, 2023
10.1111/bph.16271.

原著　Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi.
NRF2 signalling in cytoprotection and metabolism.
British Journal of Pharmacology , in press, 2023
10.1111/bph.16246.

原著　Shingo Kasamatsu, Takuma Owaki, Somei Komae, Ayaka Kinno, Tomoaki Ida, Takaaki Akaike, Hideshi Ihara.
Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts.
Redox Biology , 102875, 2023
10.1016/j.redox.2023.102875.

原著　Shingo Kasamatsu, Akira Nishimura, Md Morshedul Alam, Masanobu Morita, Kakeru Shimoda, Tetsuro Matsunaga, Minkyung Jung, Seiryo Ogata, Uladzimir Barayeu, Tomoaki Ida, Motohiro Nishida, Akiyuki Nishimura, Hozumi Motohashi, Takaaki Akaike.
Supersulfide catalysis for nitric oxide and aldehyde metabolism.
Science Advance, 9(33): eadg8631, 2023
10.1126/sciadv.adg8631.

原著　Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi.
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop.
Redox Biology, 65: 102834, 2023
10.1016/j.redox.2023.102834.

原著　Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike.
Supersulphides provide airway protection in viral and chronic lung diseases.
Nature Communications, 14(1): 4476, 2023
10.1038/s41467-023-40182-4.

原著　Shingo Kasamatsu, Ayaka Kinno, Jun-Ichi Hishiyama, Takaaki Akaike, Hideshi Ihara.
Development of methods for quantitative determination of the total and reactive polysulfides: Reactive polysulfide profiling in vegetables.
Food Chemistry , 413: 135610, 2023
10.1016/j.foodchem.2023.135610.

原著　Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya.
Cystathionine γ-lyase self-inactivates by polysulfidation during cystine metabolism.
International Journal of Molecular Sciences, 24(12): 9982, 2023
10.3390/ijms24129982

原著　Ayaka Kinno, Shingo Kasamatsu, Takaaki Akaike, Hideshi Ihara.
Reactive sulfur species omics analysis in the brain tissue of the 5xFAD mouse model of Alzheimer's disease.
Antioxidants, 12(5): 1105 , 2023
10.3390/antiox12051105.

原著　Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike.
Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism.
Antioxidants, 12(4): 868, 2023
10.3390/antiox12040868.

原著　Takayuki Shimizu, Tomoaki Ida, Giuliano T Antelo, Yuta Ihara, Joseph N Fakhoury, Shinji Masuda, David P Giedroc, Takaaki Akaike, Daiana A Capdevila, Tatsuru Masuda.
Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics.
PNAS Nexus, 2(3): pgad048, 2023
10.1093/pnasnexus/pgad048.

原著　Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi.
Contribution of NRF2 to sulfur metabolism and mitochondrial activity.
Redox Biology , 60: 102624, 2023
10.1016/j.redox.2023.102624.

原著　Xiaokang Tang, Akiyuki Nishimura, Kohei Ariyoshi, Kazuhiro Nishiyama, Yuri Kato, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung-Kyu Kim, Jin Han, Yasunari Kanda, Keitaro Umezawa, Yasuteru Urano, Takaaki Akaike, Motohiro Nishida.
Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial infarction in mice.
Marine Drugs, 21(1): 52 , 2023
10.3390/md21010052.

原著　Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J Lamb, Jordan J Lee, Michael P Frenneaux, Jon M Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani.
Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?
Redox Biology , 60: 102605, 2023
10.1016/j.redox.2023.102605.

原著　Hirai T, Ikeda-Imafuku M, Tasaka N, Tuan Giam Chuang V, Xian M, Ishida T, Akaike T, Ishima Y.
Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides.
Adv. Redox Res, 10 :100091, 2024
10.1016/j.arres.2023.100091: https://www.sciencedirect.com/science/article/pii/S2667137923000310

原著　Yuji Sasama, Kentaro Yoshimura, Marie Hoshino, Kiyohito Sasa, Takaaki Akaike, Masanobu Morita, Kazuyoshi Baba, Tatsuo Shirota, Yoichi Miyamoto.
Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates.
Journal of Oral Biosciences , 66(1): 76-81, 2023
10.1016/j.job.2023.11.004.

原著　Jiangning Yang, Michaela L. Sundqvist, Xiaowei Zheng, Tong Jiao, Aida Collado, Yahor Tratsiakovich, Ali Mahdi, John Tengbom, Evanthia Mergia, Sergiu-Bogdan Catrina, Zhichao Zhou, Mattias Carlström, Takaaki Akaike, Miriam M. Cortese-Krott, Eddie Weitzberg, Jon O. Lundberg, John Pernow.
Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP.
J Clin Invest, 1;133(17):e167693, 2023
10.1172/JCI167693.

原著　Hiroshi Tawarayama, Kota Umeki, Maki Inoue-Yanagimachi, Naoki Takahashi, Hirokazu Hasegawa, Noriko Himori, Satoru Tsuda, Hiroshi Kunikata, Takaaki Akaike, Toru Nakazawa.
Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells.
Scientific Reports, 13(1): 11513, 2023
10.1038/s41598-023-38696-4

原著　Shinichiro Horii, Hirofumi Sugawara, Hitoshi Goto, Munetaka Hashimoto, Tetsuro Matsunaga, Daijirou Akamatsu, Yuta Tajima, Michihisa Umetsu, Takaaki Akaike, Takashi Kamei.
Presence of Helicobacter cinaedi in atherosclerotic abdominal aortic aneurysmal wall.
The Tohoku Journal of Experimental Medicine , 261(1): 35-41, 2023
10.1620/tjem.2023.J049

原著　Hisyam Abdul Hamid, Tsuyoshi Takata, Tetsuro Matsunaga, Takaaki Akaike.
A persulfide shield.
Sulfurtransferases , 101-117 , 2023
10.1016/b978-0-443-18827-5.00001-7

総説　Tianli Zhang, Takaaki Akaike, Tomohiro Sawa.
Redox regulation of xenobiotics by reactive sulfur and supersulfide species.
Antioxidants & Redox Signaling, 40(10-12): 679-690, 2024
10.1089/ars.2022.0172.

総説　Seiryo Ogata, Tetsuro Matsunaga, Minkyung Jung, Uladzimir Barayeu, Masanobu Morita, Takaaki Akaike.
Persulfide biosynthesis conserved evolutionarily in all organisms.
Antioxidants & Redox Signaling , 39(13-15): 983-999, 2023
10.1089/ars.2023.0405

原著　Shieh M, Ni X, Xu S, Lindahl SP, Yang M, Matsunaga T, Flaumenhaft R, Akaike T, Xian M.
Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs.
Redox Biol., 56, 2022
10.1016/j.redox.2022.102433: https://doi.org/10.1016/j.redox.2022.102433

原著　Kunikata H, Tawarayama H, Tsuda S, Akaike T, Nakazawa T.
Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides.
Sci. Rep., 12(1), 2022
10.1038/s41598-022-21677-4: https://www.nature.com/articles/s41598-022-21677-4

原著　Anzai H, Shindo Y, Kohata Y, Hasegawa M, Takana H, Matsunaga T, Akaike T, Ohta M.
Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing.
Sci. Rep., 12(1), 2022
10.1038/s41598-022-18788-3: https://www.nature.com/articles/s41598-022-18788-3

原著　4Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol., 57, 2022
10.1016/j.redox.2022.102514: https://doi.org/10.1016/j.redox.2022.102514

原著　Tsutsuki H, Zhang T, Yahiro K, Ono K, Fujiwara Y, Iyoda S, Wei FY, Monde K, Seto K, Ohnishi M, Oshiumi H, Akaike T, Sawa T.
Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection.
iScience, 25(4), 2022
10.1016/j.isci.2022.104050: https://doi.org/10.1016/j.isci.2022.104050

原著　Kasamatsu S, Tsutsuki H, Ida T, Sawa T, Watanabe Y, Akaike T, Ihara H.
Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants.
Nitric Oxide, 120, 2022
10.1016/j.niox.2022.01.004: https://doi.org/10.1016/j.niox.2022.01.004

原著　Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma YT, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M.
Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.
Sci. Signal., 15(716), 2022
10.1126/scisignal.abj0644: https://www.science.org/doi/10.1126/scisignal.abj0644

原著　Kaneko K, Miyamoto Y, Ida T, Morita M, Yoshimura K, Nagasaki K, Toba K, Sugisaki R, Motohashi H, Akaike T, Chikazu D, Kamijo R.
8-Nitro-cGMP suppresses mineralization by mouse osteoblasts.
J. Clin. Biochem. Nutr., 71(3), 2022
10.3164/jcbn.21-129: https://www.jstage.jst.go.jp/article/jcbn/71/3/71_21-129/_article

原著　Kurane T, Matsunaga T, Ida T, Sawada K, Nishimura A, Fukui M, Umemura M, Nakayama M, Ohara N, Matsumoto S, Akaike T, Matsuzaki G, Takaesu G.
GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
FASEB J., 36(1), 2022
10.1096/fj.202101074RR: https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202101074RR

原著　Hayashi K, Asai S, Umezawa K, Kakizoe H, Miyachi H, Morita M, Akaike T, Kuno H, Komatsu S, Watanabe T, Kawahara T.
Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS-CoV-2 as assessed by a plaque assay.
J. Clin. Lab. Anal., 36(1), 2022
10.1002/jcla.24146: https://doi.org/10.1002/jcla.24146

原著　Tawarayama H, Suzuki N, Inoue-Yanagimachi M, Himori N, Tsuda S, Sato K, Ida T, Akaike T, Kunikata H, Nakazawa T.
Glutathione trisulfide prevents lipopolysaccharide-induced inflammatory gene expression in retinal pigment epithelial cells.
Ocul. Immunol. Inflamm., 30(4), 2020
10.1080/09273948.2020.1833224: https://doi.org/10.1080/09273948.2020.1833224

原著　Erdélyi K, Ditrói T, Johansson HJ, Czikora Á, Balog N, Silwal-Pandit L, Ida T, Olasz J, Hajdú D, Mátrai Z, Csuka O, Uchida K, Tóvári J, Engebraten O, Akaike T, Børresen Dale AL, Kásler M, Lehtiö J, Nagy P.
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation.
Proc. Natl. Acad. Sci. USA., 118(45), 2021
10.1073/pnas.2100050118: https://doi.org/10.1073/pnas.2100050118

原著　Takata T, Jung M, Matsunaga T, Ida T, Morita M, Motohashi H, Shen X, Kevil CG, Fukuto JM, Akaike T.
Methods in sulfide and persulfide research.
Nitric Oxide, 116, 2021
10.1016/j.niox.2021.09.002: https://doi.org/10.1016/j.niox.2021.09.002

原著　Komae S, Kasamatsu S, Uchida K, Ihara H.
Quantitative determination of 2-oxo-imidazole-containing dipeptides by high-performance liquid chromatography/tandem mass spectrometry.
Antioxidants (Basel), 11(12), 2021
10.3390/antiox11122401: https://doi.org/10.3390/antiox11122401

原著　Balasubramanian R, Hori K, Shimizu T, Kasamatsu S, Okamura K, Tanaka K, Ihara H, Masuda S.
The sulfide-responsive SqrR/BigR homologous regulator YgaV of Escherichia coli controls expression of anaerobic respiratory genes and antibiotic tolerance.
Antioxidants (Basel), 11(12), 2022
10.3390/antiox11122359: https://doi.org/10.3390/antiox11122359

原著　Komae S, Kasamatsu S, Ihara H.
2-Oxo-imidazole dipeptides in meat.
Biosci. Biotechnol. Biochem., 86(11), 2022
10.1093/bbb/zbac138: https://doi.org/10.1093/bbb/zbac138

原著　Ueda Y, Zhao W, Ihara H, Imahori Y, Tsantili E, Wendakoon SK, Chambers A, Bai J.
Functional characteristics of aldehyde dehydrogenase and its involvement in aromatic volatile biosynthesis in postharvest banana ripening.
Foods., 11(3), 2022
10.3390/foods11030347: https://doi.org/10.3390/foods11030347

総説　Sawa T, Akaike T.
What triggers inflammation in COVID-19?
elife, 11, 2022
10.7554/eLife.76231: https://doi.org/10.7554/eLife.76231

A02　本橋　ほづみ

原著　Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H.
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.
Nat Metab, in press., 2024

原著　Nishimura A, Yoon S, Matsunaga T, Ida T, Jung M, Ogata S, Morita M, Yoshitake J, Unno Y, Barayeu U, Takata T, Takagi H, Motohashi H, van der Vliet A, Akaike T.
Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality.
Redox Biol., 69:103018, 2024
10.1016/j.redox.2023.103018.

原著　Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H, Akaike T.
Supersulfide catalysis for nitric oxide and aldehyde metabolism.
Sci Adv, 9(33):eadg8631, 2023
10.1126/sciadv.adg8631.

原著　Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H, Akaike T.
Supersulphides provide airway protection in viral and chronic lung diseases.
Nat Commun, 14(1):4476, 2023
10.1038/s41467-023-40182-4

総説　Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T.
Supersulfide biology and translational medicine for disease control.
Br J Pharmacol, Epub ahead of print, 2023
10.1111/bph.16271

総説　Murakami S, Kusano Y, Okazaki K, Akaike T, Motohashi H.
NRF2 signalling in cytoprotection and metabolism.
Br J Pharmacol, Epub ahead of print, 2023
10.1111/bph.16246

総説　草野佑典、村上昌平、本橋ほづみ
エネルギー代謝におけるKEAP1-NRF2制御系と硫黄代謝の役割
化学と生物, 61 (4), 188-195, 2023

総説　村上昌平、成恩圭、本橋ほづみ
NRF2活性化による抗老化作用に関わる分子機構．特集「抗老化医療の、未来をさぐる：哺乳類における老化・寿命制御の理解とその社会実装」
老年医学, 61(1),１55-61, 2023

総説　本橋ほづみ
環境化学物質に対する生体応答を担う転写制御．特集「環境科学物質と生体応答」
Medical Science Digest, 49 (1), 677-680, 2023

原著　Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi.
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop.
Redox Biol., 65, 2023
https://doi.org/10.1016/j.redox.2023.102834

原著　Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi.
Contribution of NRF2 to sulfur metabolism and mitochondrial activity.
Redox Biology., Volume 60, 2023
10.1016/j.redox.2023.102624: https://doi.org/10.1016/j.redox.2023.102624

原著　Zhao M, Murakami S, Matsumaru D, Kawauchi T, Nabeshima YI, Motohashi H.
NRF2 Pathway Activation Attenuates Aging-Related Renal Phenotypes due to α-Klotho Deficiency.
J Biochem., 171(5), 2022
10.1093/jb/mvac014: https://doi.org/10.1093/jb/mvac014

原著　Okazaki K, Anzawa H, Katsuoka F, Kinoshita K, Sekine H, Motohashi H.
CEBPB is Required for NRF2-Mediated Drug Resistance in NRF2-Activated Non-Small Cell Lung Cancer Cells.
J Biochem., 171(5), 2022
10.1093/jb/mvac013: https://doi.org/10.1093/jb/mvac013

原著　Kitamura H, Oishi T, Murakami S, Yamada-Kato T, Okunishi I, Yamamoto M, Katori Y, Motohashi H.
Establishment of Neh2-Cre:tdTomato Reporter Mouse for Monitoring the Exposure History to Electorphilic Stress.
Free Radical Biol Med, 193(2), 2022
10.1016/j.freeradbiomed.2022.11.004: https://doi.org/10.1016/j.freeradbiomed.2022.11.004

原著　Patel SD, Anand D, Motohashi H, Katsuoka F, Yamamoto M, Lachke SA.
Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects.
Front Cell Dev Biol., 10, 2022
10.3389/fcell.2022.981893: https://www.frontiersin.org/articles/10.3389/fcell.2022.981893/full

原著　Sengoku T, Shiina M, Suzuki K, Hamada K, Sato K, Uchiyama A, Kobayashi S, Oguni A, Itaya H, Kasahara K, Moriwaki H, Watanabe C,
Honma T, Okada C, Baba S, Ohta T, Motohashi H, Yamamoto M, Ogata K.
Structural basis of transcription regulation by CNC family transcription factor, Nrf2.
Nucleic Acids Res., 50(21), 2022
10.1093/nar/gkac1102: https://doi.org/10.1093/nar/gkac1102

総説　Matsumaru D, Motohashi H.
The KEAP1-NRF2 System in Healthy Aging and Longevity.
Antioxidants (Basel), 10(12), 2021
10.3390/antiox10121929: https://doi.org/10.3390/antiox10121929

総説　Kitamura H, Takeda H, Motohashi H
Genetic, metabolic and immunological features of cancers with NRF2 addiction.
FEBS Lett, 596(16), 2022
10.1002/1873-3468.14458: https://doi.org/10.1002/1873-3468.14458

原著　Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K.
Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Int J Mol Sci, 23(6), 2022
10.3390/ijms23063201: https://doi.org/10.3390/ijms23063201

原著　Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K.
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Int J Mol Sci, 23(15), 2022
10.3390/ijms23158433: https://doi.org/10.3390/ijms23158433

原著　Sehsah R, Wu W, Ichihara S, Hashimoto N, Zong C, Yamazaki K, Sato H, Itoh K, Yamamoto M, Elsayed AA, El-Bestar S, Kamel E, Ichihara G.
Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility.
Toxicol Lett, 370, 2022
10.1016/j.toxlet.2022.09.004: https://doi.org/10.1016/j.toxlet.2022.09.004

原著　Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K.
Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment.
Curr Res Transl Med, 71, 2022
110.1016/j.retram.2022.103367: https://doi.org/10.1016/j.retram.2022.103367

原著　Iwamura H, Mizuno K, Akamatsu S, Hatakeyama S, Tobisawa Y, Narita S, Narita T, Yamashita S, Kawamura S, Sakurai T, Fujita N, Kodama H, Noro D, Kakizaki I, Nakaji S, Itoh K, Tsuchiya N, Ito A, Habuchi T, Ohyama C, Yoneyama T.
Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases.
Cancer Sci, 113, 2022
10.1111/cas.15395: https://doi.org/10.1111/cas.15395

総説　Hasegawa T, Kakuta M, Yamaguchi R, Sato N, Mikami T, Murashita K, Nakaji S, Itoh K, Imoto S.
Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population.
Sci Rep, 12, 2022
10.1038/s41598-022-11730-7: https://www.nature.com/articles/s41598-022-11730-7

総説　Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A.
Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.
J Hum Genet, 67, 2022
10.1038/s10038-022-01011-6: https://www.nature.com/articles/s10038-022-01011-6

A02　魏　范研

A02　石丸　泰寛

原著　Taro Yamanashi, Shouki Takeshi, Shota Sasaki, Keisuke Takashima, Toshiro Kaneko, Yasuhiro Ishimaru, Nobuyuki Uozumi.
Utilizing plasma-generated N2O5 gas from atmospheric air as a novel gaseous nitrogen source for plants.
Plant Mol. Biol., 114, 35, 2024
10.1007/s11103-024-01438-9

原著　Takeshi Uchiyama, Shunya Saito, Taro Yamanashi, Megumi Kato, Kosuke Takebayashi, Shin Hamamoto, Masaru Tsujii, Tomoko Takagi, Noriko Nagata, Hayato Ikeda, Hidetoshi Kikunaga, Toshimi Suda, Sho Toyama, Misako Miwa, Shigeo Matsuyama, Mitsunori Seo, Tomoaki Horie, Takashi Kuromori, Mutsumi Yamagami, Yasuhiro Ishimaru, Nobuyuki Uozumi.
The HKT1 Na+ transporter protects plant fertility by decreasing Na+ content in stamen filaments.
Sci. Adv., 9, eadg5495, 2023
10.1126/sciadv.adg5495

原著　Hiraku Kishimoto, Chihiro Azai, Tomoya Yamamoto, Risa Mutoh, Tetsuko Nakaniwa, Hideaki Tanaka, Yohei Miyanoiri, Genji Kurisu, Hirozo Oh-oka.
Soluble domains of cytochrome c-556 and Rieske iron–sulfur protein from Chlorobaculum tepidum: Crystal structures and interaction analysis.
Curr. Res. Struct. Biol., 5, 100101, 2023
10.1016/j.crstbi.2023.100101

原著　Ayumu Kobayashi, Masamune Nakamura, Masaru Tsujii, Kohei Makino, Tatsuya Nagayama, Kensuke Nakamura, Kei Nanatani, Kera Kota, Yuki Furuuchi, Shunsuke Kayamori, Tadaomi Furuta, Iwane Suzuki, Yoshihiro Hayakawa, Ellen Tanudjaja, Yasuhiro Ishimaru, Nobuyuki Uozumi.
Two cyanobacterial response regulators with diguanylate cyclase activity, Rre2 and Rre8, participate in biofilm formation.
Mol. Microbiol, 119, 599-611, 2023
10.1111/mmi.15057

原著　Ellen Tanudjaja, Naomi Hoshi, Kaneyoshi Yamamoto, Kunio Ihara, Tadaomi Furuta, Masaru Tsujii, Yasuhiro Ishimaru, Nobuyuki Uozumi.
Two Trk/Ktr/HKT-type potassium transporters, TrkG and TrkH perform distinct functions in Escherichia coli K-12.
J. Biol. Chem, 299, 102846, 2023
10.1016/j.jbc.2022.102846

原著　Sato K, Saito S, Endo K, Kono M, Kakei T, Taketa H, Kato M, Hamamoto S, Grenzi M, Costa A, Munemasa S, Murata Y, Ishimaru Y, Uozumi N.
Green tea catechins, (−)-Catechin Gallate, and (−)-Gallocatechin Gallate are potent inhibitors of ABA-induced stomatal closure.
Advanced Science, 9, 21, 2022
10.1002/advs.202201403: https://doi.org/10.1002/advs.202201403

原著　Yamanashi T, Uchiyama T, Saito S, Higashi T, Ikeda H Kikunaga H, Yamagami M, Ishimaru Y, and Uozumi N.
Potassium transporter KUP9 participates in K+ distribution in roots and leaves under low K+ stress.
Stress Biology, volume 2, 52, 2022
10.1007/s44154-022-00074-x: https://doi.org/10.1007/s44154-022-00074-x

原著　Yang G, Ishimaru Y, Hoshino S, Muraoka Y, Uozumi N, Ueda M.
12-Hydroxyjasmonic acid glucoside causes leaf-folding of Samanea saman through ROS accumulation.
Scientific Reports, 12, 1, 2022
10.1002/advs.202201403: https://doi.org/10.1038/s41598-022-11414-2

総説　佐藤 奏音、石丸 泰寛、魚住 信之
「バイオスティミュラントハンドブック」
エヌ・ティー・エス社, 第1編第5章第1節, 147-153, 2022
http://www.nts-book.co.jp/item/detail/summary/bio/20220500_265.html

総説　辻井 雅、石丸 泰寛、魚住 信之
植物における硫黄代謝と光合成制御
生化学, 93巻5号, 643-650, 2021
10.14952/SEIKAGAKU.2021.930643: https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2021.930643/data/index.html

A02　澤　智裕

原著　Toyomoto T, Ono K, Shiba T, Momitani K, Zhang T, Tsutsuki H, Ishikawa T, Hoso K, Hamada K, Rahman A, Wen L, Maeda Y, Yamamoto K, Matsuoka M, Hanaoka K, Niidome T, Akaike T, *Sawa T.
Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics.
Front Microbiol., 27;14:1276447, 2023
10.3389/fmicb.2023.1276447.

原著　Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, *Motohashi H.
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop.
Redox Biol., 65:102834, 2023
10.1016/j.redox.2023.102834.

原著　Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H, Akaike T.
Supersulphides provide airway protection in viral and chronic lung diseases.
Nat Commun., 14(1):4476, 2023
10.1038/s41467-023-40182-4

原著　Ikeda-Imafuku M, Fukuta T, Tuan Giam Chuang V, Sawa T, Maruyama T, Otagiri M, Ishida T, Ishima Y.
Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.
Pharmaceuticals (Basel), 17(1): 128., 2024
10.3390/ph17010128.: https://www.mdpi.com/1424-8247/17/1/128

原著　Lindahl S, Shieh M, Zhang T, Guo C, Robinson JR, *Sawa T, *Xian M.
Thioglucose-derived tetrasulfide, a unique polysulfide model compound.
Redox Biol., 70:103045, 2024
10.1016/j.redox.2024.103045

原著　Matsunaga, S., Kohda, A., Kamakura, S., Hayase, J., Miyano, K., Shiose, A., and *Sumimoto, H.
Hypoxia stabilizes the H2O2-producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation.
Genes Cells, 29, 63–72., 2024
10.1111/gtc.13085

原著　Kamakura, S., Hayase, J., Kohda, A., Iwakiri, Y., Chishiki, K, Izaki, T., and *Sumimoto, H.
TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development.
EMBO Rep., 25, 144–167, 2024
10.1038/s44319-023-00018-0

原著　Boussaty, E.C., Ninoyu, Y., Andrade, L., Li, Q., Takeya, R., Sumimoto, H., Ohyama, T., Wahlin, K.J., Manor, U., and *Friedman, R.A.
Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate.
PLoS Genet, 20, e1011211, 2024
10.1371/journal.pgen.1011211.

総説　Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T.
Supersulfide biology and translational medicine for disease control.
Br J Pharmacol, Epub ahead of print, 2023
10.1111/bph.16271

総説　Tianli Zhang, Takaaki Akaike, Tomohiro Sawa.
Redox regulation of xenobiotics by reactive sulfur and supersulfide species.
Antioxidants & Redox Signaling, 40(10-12): 679-690, 2024
10.1089/ars.2022.0172.

総説　Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa.
Regulation of innate immune and inflammatory responses by supersulfides.
International Immunology , 36(4): 143-154, 2024
10.1093/intimm/dxad057

原著　Tsubasa Sakurai, Sachiko Kamakura, Junya Hayase, Akira Kohda, Masafumi Nakamura, Hideki Sumimoto.
GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity.
J. Biol. Chem., 298, 2022
10.1016/j.jbc.2022.102475: https://doi.org/10.1016/j.jbc.2022.102475

原著　Vlad Tocan, Junya Hayase, Sachiko Kamakura, Akira Kohda, Shouichi Ohga, Motoyuki Kohjima, Hideki Sumimoto.
Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl.
J. Biol. Chem., 297, 2021
10.1016/j.jbc.2021.101354: https://doi.org/10.1016/j.jbc.2021.101354

総説　Tomohiro Sawa, Tsuyoshi Takata, Tetsuro Matsunaga, Hideshi Ihara, Hozumi Motohashi, and Takaaki Akaike.
Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of Polysulfides as a Determinant of Physiological Functions.
Antioxid Redox Signal, 36, 2022
10.1089/ars.2021.0170: https://doi.org/10.1089/ars.2021.0170

総説　Tianli Zhang, Hiroyasu Tsutsuki, Xiaoyan Li, Tomohiro Sawa.
New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses.
J. Biochem., 171, 2022
10.1093/jb/mvab158: https://doi.org/10.1093/jb/mvab158

総説　Sumimoto H, Kohda A, Hayase J, and Kamakura S.
The NADPH oxidase activator p67phox and its related proteins.
NADPH Oxidases Revisited: From Function to Structure, Pick, E., ed. (Berlin, Springer Nature), 2023
https://www.kinokuniya.co.jp/f/dsg-02-9783031237515

A02　潮田　亮

原著　Kaiku Uegaki, Yuji Tokunaga, Michio Inoue, Seiji Takashima, Kenji Inaba, Koh Takeuchi, Ryo Ushioda, Kazuhiro Nagata(*Corresponding author)
The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER.
Cell Rep., 42(7), 2023
https://doi.org/10.1016/j.celrep.2023.112742
プレスリリース： https://www.kyoto-su.ac.jp/news/2023_ls/20230725_400a_ronbun.html

原著　Shohei Fujii, Ryo Ushioda* and Kazuhiro Nagata*.
Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors.
Proc Natl Acad Sci U S A. 2023 May 30;120(22)
10.1038/s41598-022-11342-1: https://doi.org/10.1073/pnas.2216857120
プレスリリース： https://www.kyoto-su.ac.jp/news/2023_ls/20230524_400a_ronbun.html

原著　Hiroki Tanemura, Kenji Masuda, Takeshi Okumura, Eri Takagi, Daisuke Kajihara, Hirofumi Kakihara, Koichi Nonaka, Ryo Ushioda*.
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells.
Scientific Reports, 12(1), 2022
10.1038/s41598-022-11342-1: https://www.nature.com/articles/s41598-022-11342-1

原著　Riyuji Yamashita, Shohei Fujii, Ryo Ushioda*, Kazuhiro Nagata*.
Ca2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation.
Scientific Reports, 11(1), 2021
10.1038/s41598-021-99980-9: https://www.nature.com/articles/s41598-021-99980-9

総説　上垣 日育、永田 和宏、潮田 亮
小胞体プロテオスタシスの新常識―酸化反応の場としての小胞体から還元反応の場へ
実験医学増刊, Vol.40, No.12, 2022

総説　藤井 唱平、潮田 亮
タンパク質品質管理を支える小胞体レドックス環境と電子伝達
生化学, Vol.93, No.5, 2021

A03　西田　基宏

原著　Yamada S, Hashita T, Yanagida S, Sato H, Yasuhiko Y, Okabe K, Noda T, Nishida M, Matsunaga T, Kanda Y.
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway.
Fluids Barriers CNS, 21(1):32, 2024
10.1186/s12987-024-00533-9

原著　Cui Q, Shieh M, Pan TW, Nishimura A, Matsunaga T, Kelly SS, Xu S, Jung M, Ogata S, Morita M, Yoshitake J, Chen X, Robinson JR, Qian WJ, Nishida M, Akaike T*, Xian M*.
2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels.
Nat. Commun, 15, 2453, 2024

原著　Nishiyama K, Kato Y, Nishimura A, Mi X, Nagata R, Mori Y, Azuma Y and Nishida M*.
Pharmacological activation of TRPC6 channel prevents colitis progression.
Int. J. Mol. Sci, 25, 2401, 2024

原著　Nishimura A*, Zhou L, Kato Y, Mi X, Ito T, Ibuki Y, Kanda Y, Nishida M*.
Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation.
J. Pharmacol. Sci, 2024

原著　Chuntakaruk H, Hengphasatporn K*, Shigeta Y, Aonbangkhen C, Lee VS, Khotavivattana T*, Rungrotmongkol T*, Hannongbua S*.
FMO-guided design of darunavir analogs as HIV-1 protease inhibitors.
Sci. Rep, 14, 3639, 2024

原著　Chuntakaruk H, Boonpalit K, Kinchagawat J, Nakarin F, Khotavivattana T, Aonbangkhen C, Shigeta Y, Hengphasatporn K*, Nutanong S*, Rungrotmongkol T*, Hannongbua S.
Machine learning-guided design of potent darunavir analogs targeting HIV-1 proteases: A computational approach for antiretroviral drug discovery.
J. Comput. Chem, 45, 953-968, 2024

原著　Katsuda Y, Kamura T, Kida T, Saeki T, Itsuki Y, Kato Y, Nakamura T, Nishida M, Kitamura Y, Ihara T, Hagihara M, Sato S.
In vivo mRNA hacking with staple oligomers prevents myocardial hypertrophy.
BioRxiv, 2023
10.1101/2023.04.18.537290

原著　Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M*, Inoue A*, Wei FY*.
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction.
Commun. Biol, 6, 511, 2023

原著　Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H and Akaike T*.
Supersulfide catalysis for nitric oxide and aldehyde metabolism.
Science Adv, 9, eadg8631, 2023

原著　Nishiyama K, Ariyoshi K, Nishimura A, Kato Y, Mi X, Kurose H, Kim SG and Nishida M*.
Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
Int. J. Mol. Sci., 24, 3800, 2023

原著　Tang X, Nishimura A, Ariyoshi K, Nishiyama K, Kato Y, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Kanda Y, Umezawa K, Urano Y, Akaike T and Nishida M*.
Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice.
Mar. Drugs, 21, 52, 2023

原著　Kongkaew N, Hengphasatporn K, Injongkol Y, Mee-udorn P, Shi L, Mahalapbutr P, Maitarad P*, Harada R, Shigeta Y, Rungrotmongkol T*, Vangnai AS*.
Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning.
RSC Adv., 13, 32266-32275, 2023

総説　Nishimura A*, Tang X, Zhou L, Ito T, Kato Y, Nishida M*.
Sulfur metabolism as a new therapeutic target of heart failure.
J. Pharmacol. Sci., 155, 75-83, 2024

総説　Nishida M*, Mi X, Ishii Y, Kato Y, Nishimura A.
Cardiac Remodeling: Novel Pathophysiological Mechanisms and Therapeutic Strategies.
J. Biochem, mvae031, 2024

総説　Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T*.
Supersulfide biology and translational medicine for disease control.
Br. J. Pharmacol, 2023

原著　Kato Y, Nishiyama K, Lee JM, Ibuki Y, Imai Y, Noda T, Kamiya N, Kusakabe T, Kanda Y, Nishida M*.
TRPC3-Nox2 protein complex formation increases the risk of SARS-CoV-2 Spike protein-induced cardiomyocyte dysfunction through ACE2 upregulation.
Int. J. Mol. Sci. accepted, 2022
10.3390/ijms24010102: https://doi.org/10.3390/ijms24010102

原著　Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M.
Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Nature Communications, 13, 1, 2022
10.1038/s41467-022-34194-9: https://www.nature.com/articles/s41467-022-34194-9

原著　Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species induced stress.
Redox Biology, 57, 2022
10.1016/j.redox.2022.102514: https://www.sciencedirect.com/science/article/pii/S2213231722002865?via%3Dihub

原著　Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J,
Birnbaumer L, Mori Y, Nishida M.
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
British Journal of Pharmacology, 180, 1, 2022
10.1111/bph.15942: https://doi.org/10.1111/bph.15942

原著　Shimauchi T, Numaga‐tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim S.G, Urano Y, Ohshima T, Nishida M.
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind‐Limb Ischemia.
Cells, 11, 13, 2022
10.3390/cells11132041: https://doi.org/10.3390/cells11132041

原著　Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma Y.-T, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M.
Redox-dependent internalization ofthe purinergic P2Y6 receptor limits colitis progression.
Science Signaling, 15, 716, 2022
10.1126/scisignal.abj0644: https://www.science.org/doi/10.1126/scisignal.abj0644

原著　Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A,
Hirai H, Ishido S, Yoshizawa T, Shindo T, Takada S, Kinugawa S, Inatome R, Yanagi S.
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.
iScience, 25, 7, 2022
10.1016/j.isci.2022.104582: https://doi.org/10.1016/j.isci.2022.104582

原著　Yamada S, Noda T, Okabe K, Yanagida S, Nishida M, Kanda Y.
SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium.
Journal of Pharmacological Sciences, 149, 3, 2022
10.1016/j.jphs.2022.04.010: https://doi.org/10.1016/j.jphs.2022.04.010

原著　Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sat, K, Toyama T, Yamamura Y, Miyagawa T, Yamazaki H, Hara A, Shimizu M, Furuich, K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T.
Protective effect of D-alanine against acute kidney injury.
American Journal of Physiology - Renal Physiology, 322, 6, 2022
10.1152/ajprenal.00198.2021: https://doi.org/10.1152/ajprenal.00198.2021

原著　Murata R, Watanabe H, Nosaki H, Nishida K, Maeda H, Nishida M, Maruyama T.
Long-Acting Thioredoxin Ameliorates Doxorubicin-Induced Cardiomyopathy via Its Anti-Oxidative and Anti-Inflammatory Action.
Pharmaceutics, 14, 3, 2022
10.3390/pharmaceutics14030562: https://doi.org/10.3390/pharmaceutics14030562

原著　Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, Kanda Y.
Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.
International Journal of Molecular Sciences, 23, 4, 2022
10.3390/ijms23041967: https://doi.org/10.3390/ijms23041967

原著　Masuda A, Lee J.M, Miyata T, Mon H, Sato K, Oyama K, Sakurai Y, Yasuda J, Takahashi D, Ueda T, Kato Y, Nishida M, Karasaki N, Kakino K, Ebihara T, Nagasato T, Hino M, Nakashima A, Suzuki K, Tonooka Y, Tanaka M, Moriyama T, Nakatake H, Fujita R, Kusakabe T.
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants.
Frontiers in Immunology, 12, 2022
10.3389/fimmu.2021.803647: https://doi.org/10.3389/fimmu.2021.803647

原著　Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada K.-I.
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques.
Nature Communications, 12, 1, 2021
10.1038/s41467-021-26633-w: https://www.nature.com/articles/s41467-021-26633-w

原著　Marutani E, Morita M, Hirai S, Kai S, Grange R.M.H, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker D.R,
Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin D.N, Ihara H, Olenchock B.A, Shen X, Nishida M, Hanaoka K, Kevil C.G, Xian M, Bloch D.B, Akaike T, Hindle A.G, Motohashi H, Ichinose F.
Sulfide catabolism ameliorates hypoxic brain injury.
Nature Communications, 12, 1, 2021
10.1038/s41467-021-23363-x: https://www.nature.com/articles/s41467-021-23363-x

総説　Kato Y, Nishiyama K, Nishimura A, Noda T, Okabe K, Kusakabe T, Kanda Y, Nishida M.
Drug repurposing for the treatment of COVID-19.
Journal of Pharmacological Sciences, 149, 3, 2021
10.1016/j.jphs.2022.04.007: https://www.sciencedirect.com/science/article/pii/S1347861322000342

総説　Nishimura A, Tanaka T, Kato Y, Nishiyama K, Nishida M.
Cardiac robustness regulated by reactive sulfur species.
Journal of Clinical Biochemistry and Nutrition, 70, 1, 2021
10.3164/JCBN.21-84: https://doi.org/10.3164/jcbn.21-84

A03　増田　真二

原著　Tomo Kondo, Takayuki Shimizu.
Translation Enhancement by a Short Nucleotide Insertion at 5′UTR: Application to an In Vitro Cell-Free System and a Photosynthetic Bacterium.
Appl. Microbiol., 3(3), 2023
10.3390/applmicrobiol3030047: https://doi.org/10.3390/applmicrobiol3030047

原著　Takayuki Shimizu, Tomoaki Ida, Giuliano T Antelo, Yuta Ihara, Joseph N Fakhoury, Shinji Masuda, David P Giedroc, Takaaki Akaike, Daiana A Capdevila, Tatsuru Masuda.
Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics.
PNAS Nexus, 2(3), 2023
10.1093/pnasnexus/pgad048: https://doi.org/10.1093/pnasnexus/pgad048

原著　Takayuki Shimizu, Masaru Hashimoto, Tatsuru Masuda.
Thioredoxin-2 Regulates SqrR-Mediated Polysulfide-Responsive Transcription via Reduction of a Polysulfide Link in SqrR.
Antioxidants, 12(3), 2023
10.3390/antiox12030699: https://doi.org/10.3390/antiox12030699

原著　Balasubramanian R, Hori K, Shimizu T, Kasamatsu S, Okamura K, Tanaka K, Ihara H, Masuda S.
The sulfide-responsive SqrR/BigR homologous regulator YgaV of Escherichia coli controls expression of anaerobic respiratory genes and antibiotic tolerance.
Antioxidants, 11, 12, 2022
10.3390/antiox11122359: https://doi.org/10.3390/antiox11122359
東京工業大学HP: https://www.titech.ac.jp/news/2022/065541

原著　Shimizu T, Aritoshi T, Beatty J.T and Masuda T.
Persulfide-responsive transcription factor SqrR regulates gene transfer and biofilm formation via the metabolic modulation of cyclic di-GMP in Rhodobacter capsulatus.
Microorganisms, 10, 5, 2022
10.3390/microorganisms10050908: https://doi.org/10.3390/microorganisms10050908

原著　Ito K, Ito D, Goto M, Suzuki S, Masuda S, Iba K and Kusumi K.
Regulation of ppGpp Synthesis and Its Impact on Chloroplast Biogenesis during Early Leaf Development in Rice.
Plant and Cell Physiology, 63, 7, 2022
10.3389/fpls.2022.919896: https://link.springer.com/article/10.1007/s00425-022-03835-0

原著　Goto M, Oikawa A, Masuda S.
Metabolic changes contributing to large biomass production in the Arabidopsis ppGpp-accumulating mutant under nitrogen deficiency.
Planta, 255, 2, 2022
10.1007/s00425-022-03835-0: https://doi.org/10.1093/pcp/pcac053

原著　Trinh M.D.L, Hashimoto A, Kano M, Takaichi S, Nakahira Y and Masuda S.
Lack of plastid-encoded Ycf10, a homolog of the nuclear-encoded DLDG1 and the cyanobacterial PxcA, enhances the induction of non-photochemical quenching in tobacco.
Plant Direct, 5, 12, 2021
10.1002/pld3.368: https://doi.org/10.1002/pld3.368

原著　Fujisawa T, Masuda S, Takeuchi S and Tahara T.
Femtosecond time-resolved absorption study of signaling state of a BLUF protein PixD from cyanobacterium Synechocystis: hydrogen bond rearrangement completes during forward proton-coupled electron transfer.
Journal of Physical Chemistry B, 125, 44, 2021
10.1021/acs.jpcb.1c05957: https://doi.org/10.1021/acs.jpcb.1c05957

総説　Trinh M.D.L and Masuda S.
Chloroplast pH homeostasis for the regulation of photosynthesis.
Front. Plant Sci.B, 13, 2022
10.3389/fpls.2022.919896: https://www.frontiersin.org/articles/10.3389/fpls.2022.919896/full

総説　清水 隆之、増田 真二
硫化水素・超硫黄分子のセンシング機構
生化学, 93(5), 2021
10.14952/SEIKAGAKU.2021.930637: https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2021.930637/index.html

A03　斎藤　芳郎

原著　Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko, Hikari Sugiura, Shota Yamashita, Yoshiteru Shimoda, Masayuki Kanamori, Kotoko Arisawa, Hidenori Endo, Yoshiro Saito.
Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
Scientific Reports, 14 (1), 682, 2024
10.1038/s41598-024-51259-5: https://doi.org/10.1038/s41598-024-51259-5

原著　Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito.
Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2.
Commuications Biology, 6 (1), 2060, 2023
10.1038/s42003-023-05449-y: https://doi.org/10.1038/s42003-023-05449-y

原著　Ayako Mizuno, Takashi Toyama, Atsuya Ichikawa, Naoko Sakai, Yuya Yoshioka, Yukina Nishito, Renya Toga, Hiroshi Amesaka, Takayuki Kaneko, Kotoko Arisawa, Ryouhei Tsutsumi, Yuichiro Mita, Shun-Ichi Tanaka, Noriko Noguchi, Yoshiro Saito.
An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase.
Journal of Biological Chemistry, 299, 105009, 2023
10.1016/j.jbc.2023.105009: https://doi.org/10.1016/j.jbc.2023.105009

原著　Takayuki Kaneko, Yuichiro Mita, Kanako Nozawa-Kumada, Masana Yazaki, Mieko Arisawa, Etsuo Niki, Noriko Noguchi, Yoshiro Saito.
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation.
Free Radical Research, 56 (9-10), 2023
10.1080/10715762.2023.2165918: https://doi.org/10.1080/10715762.2023.2165918

原著　Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi.
A non-nucleotide agonist that binds covalently to cysteine residues of STING.
Cell Structure and Function, 48, 2022
10.1247/csf.22085: https://doi.org/10.1247/csf.22085

原著　Marco Vinceti, Teresa Urbano, Annalisa Chiari, Tommaso Filippini, Lauren A. Wise, Manuela Tondelli, Bernhard Michalke, Misaki Shimizu, Yoshiro Saito.
Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.
Scientific Reports, 13, 8792, 2023
10.1038/s41598-023-36084-6: https://doi.org/10.1038/s41598-023-36084-6

原著　Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, and Spencer A. Freeman.
Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis.
Current Biology, 33, 1282–1294, 2023
10.1016/j.cub.2023.02.060: https://doi.org/10.1016/j.cub.2023.02.060

原著　Yumie Takeshita, Takeo Tanaka, Hiroaki Takayama, Yuki Kita, Hisanori Goto, Yujiro Nakano, Yoshiro Saito, Toshinari Takamura.
Circulating selenoprotein P levels predict glucose-lowering and insulinotropic effects of metformin, but not alogliptin: A post-hoc analysis.
Journal of Diabetes Investigation, 14, 2022
10.1111/jdi.13949: https://doi.org/10.1111/jdi.13949

原著　Swe Mar Oo, Hein Ko Oo, Hiroaki Takayama, Kiyo-aki Ishii, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Susumu Kohno, Chiaki Takahashi, Hiroyuki Nakamura, Yoshiro Saito, Mami Matsushita, Yuko Okamatsu-Ogura, Masayuki Saito, and Toshinari Takamura.
Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
Cell Reports, 38, 110566, 2022
10.1016/j.celrep.2022.110566: https://doi.org/10.21203/rs.3.rs-155060/v1

原著　Machiko Honda, Tatsuya Segawa, Kiyoshi Ishikawa, Masahiro Maeda, Yoshiro Saito, and Shigeyuki Kon.
Nephronectin influences EAE development by regulating Th17/Treg balance via reactive oxygen species.
American Journal of Physiology-Cell Physiology, 322(4), 2022
10.1152/ajpcell.00376.2021: https://doi.org/10.1152/ajpcell.00376.2021

原著　Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, Takashi Toyama, Kiyo-aki Ishii, Toshinari Takamura, Noriko Noguchi, and Yoshiro Saito.
Role of selenoprotein P expression in the function of pancreatic beta cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
Free Radical Biology & Medicine, 183, 2022
10.1016/j.freeradbiomed.2022.03.009: https://doi.org/10.1016/j.freeradbiomed.2022.03.009

原著　Daichi Chida, Takashi Toyama, Takanori Chiba, Takayuki Kaneko, Kotoko Arisawa and Yoshiro Saito.
Effects of the interplay between selenocystine and methylmercury on their cytotoxicity and glucose-driven insulin secretion from mouse insulinoma cells.
BPB Reports, 5, 2022
10.1248/bpbreports.5.4_74: https://doi.org/10.1248/bpbreports.5.4_74

原著　Teresa Urbano, Marco Vinceti, Jessica Mandrioli, Annalisa Chiari,Tommaso Filippini, Roberta Bedin, Manuela Tondelli, Cecilia Simonini, Giovanna Zamboni, Misaki Shimizu, and Yoshiro Saito.
Selenoprotein P concentrations in cerebrospinal fluid and serum of individuals affected by amyotrophic lateral sclerosis, mild cognitive impairment and Alzheimer’s dementia.
International Journal of Molecular Sciences, 23, 2022
10.3390/ijms23179865: https://doi.org/10.3390/ijms23179865

総説　Takashi Toyama,Runa Kudo, and Yoshiro Saito.
The Role of Supersulfide in Methylmercury Detoxification.
YAKUGAKU ZASSHI, 144(1), 41-45, 2024
10.1530/REM-22-0007: https://doi.org/10.1248/yakushi.23-00162-1

総説　Yoshiro Saito, Noriko Noguchi, Etsuo Niki.
Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides.
Free Radical Biology and Medicine, 211 (2024), 89–95, 2023
10.1016/j.freeradbiomed.2023.12.011: https://doi.org/10.1016/j.freeradbiomed.2023.12.011

総説　Noriko Noguchi, Yoshiro Saito, and Etsuo Niki.
Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging Antioxidants.
Antioxidants and Redox Signaling, 39(10-12), 728-743, 2023
10.1089/ars.2022.0191: https://doi.org/10.1089/ars.2022.0191

総説　有澤 琴子、外山 喬士、斎藤 芳郎
必須微量元素セレン研究の最前線　ダイナミクスと生理／病理的意義、重金属毒性に対する作用
ファルマシア, 59(3), 2023
10.14894/faruawpsj.59.3_179: https://doi.org/10.14894/faruawpsj.59.3_179

総説　Takashi Toyama, Takayuki Kaneko, Kotoko Arisawa, Yoshiro Saito.
Metal-binding properties of selenoprotein P—its relation to structure and function.
Metallomics Research, 2(3), p. rev-18-rev-27, 2022
10.11299/metallomicsresearch.MR202209: https://doi.org/10.11299/metallomicsresearch.MR202209

総説　斎藤芳郎
セレンと環境ストレスー生体防御におけるセレノプロテインの役割
Medical Science Digest, 49(1)

総説　有澤琴子、斎藤芳郎
鉄依存的な脂質酸化を伴う細胞死フェロトーシスに対するセレン・ビタミンEの作用
化学と生物 解説, 60(11), 2022
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202202224158923607

総説　Yoshiro Saito.
Essential trace element selenium and redox regulation- its metabolism, physiological function, and related diseases.
Redox Experimental Medicine, 1, 2022
10.1530/REM-22-0010: https://doi.org/10.1530/REM-22-0010

総説　Marco Vinceti, Tommaso Filippini, Ewa Jablonska, Yoshiro Saito, Lauren A. Wise.
Safety of selenium exposure and limitations of selenoprotein maximization: molecular and epidemiologic perspectives.
Environmental Research, 211, 113092, 2022
10.1016/j.envres.2022.113092: https://doi.org/10.1016/j.envres.2022.113092

総説　Biplab Kumar Dash, Yasuomi Urano, Yoshiro Saito and Noriko Noguchi.
Redox-sensitive DJ-1 protein: an insight into physiological roles, secretion, and therapeutic target.
Redox Experimental Medicine, 1, R96–R115, 2022
10.1530/REM-22-0007: https://doi.org/10.1530/REM-22-0007

A03　三木　裕明

原著　Osamu Hashizume, Tomofumi Kawabe, Yosuke Funato, Hiroaki Miki.
Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans.
Developmental Biology, 509, 2024, 59-69, 2024
10.1016/j.ydbio.2024.02.007.

原著　Lohani S, Funato Y, Akieda Y, Mizutani K, Takai Y, Ishitani T, and Miki H.
A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence.
J. Cell Sci., 2022
10.1242/jcs.258550: https://doi.org/10.1242/jcs.258550

原著　Ryu K, Yoshida A, Funato Y, Yamazaki D, and Miki H.
PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis.
Cell Struct. Funct., 47, 2022
10.1247/csf.22034: https://doi.org/10.1247/csf.22034

総説　Funato Y, Hashizume O, and Miki H.
Phosphatase-independent role of phosphatase of regenerating liver in cancer progression.
Cancer Sci., 114, 25-33 (2023), 2022
10.1111/cas.15625: https://doi.org/10.1111/cas.15625

総説　Funato Y and Miki H.
The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters.
J. Pharmacol. Sci., 148, 2022
10.1016/j.jphs.2021.09.004: https://doi.org/10.1016/j.jphs.2021.09.004

A01　新開　泰弘

原著　Hanako Aoki, Yasuhiro Shinkai Y, Masahiro Akiyama, Satoshi Yamazaki, Motohiro Nishida, Yoshito Kumagai.
Extracellularly Secreted Cysteine Derived from Cystine Regulates Oxidative and Electrophilic Stress in HepG2 cells.
Free Radical Research, 11:1-10, 2024
10.1080/10715762.2024.2350524

原著　Yasuhiro Shinkai, Yusuke Onose, Masahiro Akiyama, Reiko Hirose, Yoshito Kumagai.
Capture of electrophilic quinones in the extracellular space: Evidence for a phase zero reaction.
Chemical Research in Toxicology, 16;36(1):23-31, 2023
10.1021/acs.chemrestox.2c00223

原著　Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biology, 57, 2022
10.1016/j.redox.2022.102514

原著　Masahiro Akiyama, Yasuhiro Shinkai, Hiroto Yamakawa, Yun-Gi Kim, Yoshito Kumagai.
Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome.
Chemosphere, 299, 2022
10.1016/j.chemosphere.2022.134374

A01　徳永　裕二

A01　CATTI LORENZO

原著　Masaya Endo, Shinji Aoyama, Yoshitaka Tsuchido, Lorenzo Catti,* Michito Yoshizawa*.
Umbrella-shaped Amphiphiles: Internal Alkylation of an Aromatic Micelle and Its Impact on Cavity Features.
Angew. Chem. Int. Ed, 63, e202404088, 2024
10.1002/anie.202404088

A01　村上　一馬

原著　Morishita Y, Tsukada K, Murakami K, Irie K, Asai T.
Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.
Journal of Natural Products, 85, 2, 2022
10.1021/acs.jnatprod.1c00973: https://doi.org/10.1021/acs.jnatprod.1c00973

原著　Hanaki M, Murakami K, Gunji H, Irie K.
Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis.
Bioorganic and Medicinal Chemistry Letters, 61, 2022
10.1016/j.bmcl.2022.128613: https://doi.org/10.1016/j.bmcl.2022.128613

原著　Murakami K, Sakaguchi Y, Taniwa K, Izuo N, Hanaki M, Kawase T, Hirose K, Shimizu T, Irie K.
Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.
RSC Chemical Biology, 120, 2022
10.1039/d2cb00194b: https://doi.org/10.1039/D2CB00194B

総説　Murakami K, Izuo N, Bitan G.
Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.
Journal of Biological Chemistry, 298, 1, 2022
10.1016/j.jbc.2021.101478: https://doi.org/10.1016/j.jbc.2021.101478

総説　Murakami K, Ono K.
Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration.
FASEB Journal, 36, 9, 2022
10.1096/fj.202200235R: https://doi.org/10.1096/fj.202200235R

A01　松尾　和哉

A01　猪熊　　翼

原著　Inokuma T, Masui K, Fukuhara K, Yamada K.-I.
Preparation of N-2-Nitrophenylsulfenyl Imino Peptides and Their Catalyst-Controlled Diastereoselective Indolylation.
Chemistry - A European Journal, 2022
10.1002/chem.202203120: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203120

原著　Yamada K.-I, Yamauchi A, Fujiwara T, Hashimoto, Wang Y, Kuwano S, Inokuma T.
Kinetic Resolution of α-Hydroxyamide via N-Heterocyclic Carbene-Catalyzed Acylation.
Asian J. Organic Chemistry, 11(10), 2022
10.1021/acscatal.2c01579: https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202200452

原著　Wang Y, Yamauchi A, Hashimoto K, Fujiwara T, Inokuma T, Mitani Y, Ute K, Kuwano S, Yamaoka Y, Takasu K, Yamada K.
Enhanced Molecular Recognition through Substrate−Additive Complex Formation in N‑Heterocyclic-Carbene-Catalyzed Kinetic Resolution of α‑Hydroxythioamides.
ACS Catal., 12, 10, 2022
10.1002/chem.202203120: https://pubs.acs.org/doi/10.1021/acscatal.2c01579

A02　山田　健一

原著　Mori R#, Abe M#, Saimoto Y#, Shinto S, Jodai S, Tomomatsu M, Tazoe K, Ishida M, Enoki M, Kato N, Yamashita T, Itabashi Y, Nakanishi I, Ohkubo K, Kaidzu S, Tanito M, Matsuoka Y, Morimoto K, Yamada KI*.
Construction of screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases.
Redox Biol, in press, 2024
https://doi.org/10.1016/j.redox.2024.103186

原著　Tomomatsu M, Imamura N, Izumi H, Watanabe M, Ikeda M, Ide T, Uchinomiya S, Ojida A, Jutanom M, Morimoto K, Yamada KI.
Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells.
Biol. Pharm. Bull., 47(3):641-651, 2024
10.1248/bpb.b23-00849

原著　Abe M, Sou M, Matsuoka Y, Morimoto K, Yamada KI.
Ethoxyquin, a Lipid Peroxidation Inhibitor, Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion.
Biol Pharm Bull, 47(1):104-111, 2024
10.1248/bpb.b23-00538

原著　Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Sci Signal, 15(758), 2022
10.1126/scisignal.abn8017: https://doi.org/10.1126/scisignal.abn8017

原著　Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto HD, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H.
Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity.
J Cardiovasc Pharmacol., 80(5), 2022
10.1097/FJC.0000000000001328: https://journals.lww.com/cardiovascularpharm/Fulltext/2022/11000/Ethoxyquin_is_a_Competent_Radical_Trapping.9.aspx

原著　Mishima E, Ito J, Wu Z, Nakamura, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada K.-I, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão A.S.D, Linkermann A, Geissler E.K, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt D.A, Conrad M.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Nature, 608(7924), 2022
10.1038/s41586-022-05022-3: https://www.nature.com/articles/s41586-022-05022-3

原著　Yamauchi K, Matsuoka Y, Takahashi M, Izumi Y, Naka H, Taniguchi Y, Kawai K, Bamba T, Yamada K.-I.
Detection and structural analysis of pyrimidine-derived radicals generated on DNA using a profluorescent nitroxide probe.
Chemical Communications, 58, 1, 2022
10.1039/d1cc04998d: https://doi.org/10.1039/D1CC04998D

原著　Miyamoto H.D, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
JACC: Basic to Translational Science, 7, 8, 2022
10.1016/j.jacbts.2022.03.012: https://www.jacc.org/doi/abs/10.1016/j.jacbts.2022.03.012

原著　Lerksaipheng P, Paiboonsukwong, Sanvarinda P, Leuchapudiporn R, Yamada K.-I, Morales N.P.
Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol.
Biomedicine and Pharmacotherapy, 154, 2022
10.1016/j.biopha.2022.113624: https://doi.org/10.1016/j.biopha.2022.113624

総説　山田 健一
脂質由来ラジカル・酸化リン脂質の検出と構造解析
生化学, 第94巻, 第3号, 2022
10.14952/SEIKAGAKU.2022.940329: https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2022.940329/index.html

A02　椎葉　一心

A02　幸村　知子

原著　Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto H.D, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Science Signaling, 15, 758, 2022
10.1126/scisignal.abn8017: https://www.science.org/doi/10.1126/scisignal.abn8017

原著　Miyamoto H.D, Ikeda M, Ide T, Tadokoro T, Furusawa S, Abe K, Ishimaru K, Enzan N, Sada M, Yamamoto T, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
JACC: Basic to Translational Science, 7, 8, 2022
10.1016/j.jacbts.2022.03.012: https://www.jacc.org/doi/abs/10.1016/j.jacbts.2022.03.012

原著　Tadokoro T, Ikeda M, Abe K, Ide T, Miyamoto H.D, Furusawa S, Ishimaru K, Watanabe M, Ishikita A, Matsushima S, Koumura T, Yamada K.-I, Imai H, Tsutsui H.
Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity.
Journal of Cardiovascular Pharmacology, 80, 5, 2022
10.1097/FJC.0000000000001328: https://journals.lww.com/cardiovascularpharm/Fulltext/2022/11000/Ethoxyquin_is_a_Competent_Radical_Trapping.9.aspx

原著　Azuma K, Koumura T, Iwamoto R, Matsuoka M, Terauchi R, Yasuda S, Shiraya T, Watanabe S, Aihara M, Imai H, Ueta T.
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
Journal of Biological Chemistry, 298, 4, 2022
10.1016/j.jbc.2022.101824: https://doi.org/10.1016/j.jbc.2022.101824

A03　小林　麻己人

原著　Bian L, Nguyen VT, Tamaoki J, Endo Y, Dong G, Sato A and Kobayashi M.
Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish.
Redox Biol, 62, 102673, 2023
10.1016/j.redox.2023.102673

原著　Takeuchi I, Tanase-Nakao K, Ogawa A, Sugawara T, Migita O, Kashima M, Yamazaki T, Iguchi A, Naiki Y, Uchiyama T, Tamaoki J, Maeda H, Shimizu H, Kawai T, Taniguchi, Hirata H, Kobayashi M, Matsumoto K, Naruse K, Hata K, Akutsu H, Kato T, Narumi S, Arai K and Ishiguro A.
Congenital anaemia associated with loss-of-function variants i DNA polymerase epsilon 1.
J. Med. Genet, 61, 239-243, 2024
10.1136/jmg-2023-109444

原著　Zhu L, Makita S, Tamaoki J, Lichtenegger A, Zhu Y, Mukherjee Y, Lim Y, Kobayashi M and Yasuno Y.
Polarization-artifact reduction and accuracy impovement of Jones-matrix polarization-sentitive optical coherence tomography by multi-focus averaging based multiple scattering reduction. Biomed.
Opt. Express, 15, 256-276, 2024
10.1364/BOE.509763

原著　Zhu L, Makita S, Tamaoki J, Lichtenegger A, Lim Y, Zhu Y, Kobayashi M and Yasuno Y.
Multi-focus averaging for multiple scattering suppression in optical coherence tomography.
Biomed. Opt. Express, 14, 4828-4844, 2023
10.1364/BOE.493706

原著　Tamaoki J, Maeda H, Kobayashi I, Takeuchi M, Ohashi K, Gore A, Bonkhofer F, Patient R, Weinstein BM and Kobayashi M.
LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition.
Dev. Biol., 501, 92-103, 2023
10.1016/j.ydbio.2023.06.012

原著　Tomita K, Makita S, Fukutake N, Morishita R, El-Sadek IA, Mukherjee P, Lichtenegger A, Tamaoki J, Bian L, Kobayashi M, Mori T, Matsusaka S and Yasuno Y.
Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging.
2023
10.1364/BOE.491510

原著　Dong W, Akasaka I, Komiyama A, Nakamura T, Mizoguchi N, Nawaji T, Ikushiro S, Kobayashi M and Teraoka H.
Augmentation of pectoral fin teratogenicity by thalidomide in human cytochrome P450 3A-expressing zebrafish.
Pharmaceuticals , 16, 368, 2023
10.3390/ph16030368

原著　Sato Y, Dong W, Nakamura T, Mizoguchi N, Nawaji T, Nishikawa M, Onaga T, Ikushiro S, Kobayashi M and Teraoka H.
Zebrafish expressing rat cytochrome P450 2E1 (CYP2E1): augmentation of acetaminophen-induced toxicity in the liver and retina.
Int. J. Mol. Sci, 24, 4013, 2023
10.3390/ijms24044013

原著　Shashni B, Tamaoki J, Kobayashi M, Nagasaki Y.
Design of a new self-assembling antioxidant nanomedicine to ameliorate oxidative stress in zebrafish embryos.
Acta Biomater., 159, 367-381, 2023
10.1016/j.actbio.2023.01.012

原著　Saida K, Tamaoki J, Sasaki M, Haniffa M, Koshimizu E, Sengoku T, Maeda H, Kikuchi M, Yokoyama H, Sakamoto M, Iwama K, Sekiguchi F, Hamanaka K, Fujita A, Miyatake S, Mizuguchi T, Ogata K, Miyake N, Kobayashi M and Matsumoto N.
Pathogenic variants in the SMN complex gene GEMIN5 cause cerebellar atrophy.
Clin. Genet., 100(6), 722-730, 2021
10.1111/cge.14066: https://onlinelibrary.wiley.com/doi/10.1111/cge.14066

原著　Lichtenegger A, Mukherjee P, Tamaoki J, Bian L, Zhu L, El-Sadek I.A, Makita S, Leskovar K, Kobayashi M. Baumann B and Yasuno Y.
Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography.
J. Biomed., Opt.27(1), 2022
10.1117/1.JBO.27.1.016001: https://doi.org/10.1117/1.JBO.27.1.016001

原著　Watanabe A, Muraki K, Tamaoki J and Kobayashi M.
Soy-derived equol induces antioxidant activity in zebrafish in an Nrf2-independent manner.
Int. J. Mol. Sci., 23(9), 2022
10.3390/ijms23095243: https://doi.org/10.3390/ijms23095243

原著　Lichtenegger A, Tamaoki J, Licandro R, Mori T, Mukherjee1 P, Bian L, Greutter L, Makita S, Wöhrer A, Matsusaka S, Kobayashi M,
Baumann B and Yasuno Y.
Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography.
Scientific Reports, 12, 2022
10.1038/s41598-022-19483-z: https://www.nature.com/articles/s41598-022-19483-z

A03　岡田　　太

原著　Ikebuchi A, Osaki M, Wada I, Nagata H, Nagira K, Azuma Y, Okada F, Harada T, and Taniguchi F.
Increased chemokine ligand 26 expression and its involvement in epithelial-mesenchymal transition in the endometrium with adenomyosis.
J Gynecol Obstet Human Reprod , 52: 102645, 2023
10.1016/j.jogoh.2023.102645

原著　Iida Y, Sato S, Izutsu R, Seong HK, Okawa M, Osaku D, Komatsu H, Osaki M, Taniguchi F, and Okada F.
AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk.
Mol Clin Oncol, 19(1): 56, 2023
10.3892/mco.2023.2652

原著　Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujiwara K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu S-Y, Lang NB, Nakamura T, Zhang KYJ, Lipton SA, and Uehara T.
Pivotal role for S-nitrosylation of DNA methyltransferease 3B in epigenetic regulation of tumorigenesis.
Nature Commun, 14(1): 621, 2023
10.1038/s41467-023-36232-6

原著　Kitagawa T, Islam S, Baron B, Tokuda K, Paudel D, Ohta T, Nakagawa K, Kobayashi M, Okada F, and Kuramitsu Y.
A standardized extract of cultured Lentinula edodes mycelia up-regulates COX-2 in inflammation-related malignant progressive fibrosarcoma cell clone QRsP-11.
Anticancer Res, 43 (3): 1239-1244, 2023
10.21873/anticanres.16270

原著　Ueno S, Kokura K, Kuromi Y, Osaki M, Okada F, Kitamura S, Ohbayashi T.
Kidney organoid derived from renal tissue stem cells is a useful tool for histopathological assessment of nephrotoxicity in a cisplatin-induced acute renal tubular injury model.
Journal of Toxicologic Pathology, 35, 4, 2022
10.1293/tox.2022-0006: https://doi.org/10.1293/tox.2022-0006

原著　Izutsu R, Osaki M, Jehung J.P, Seong H.K, Okada F.
Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
Pathology Research and Practice, 237, 2022
10.1016/j.prp.2022.154015: https://pubmed.ncbi.nlm.nih.gov/35843033/

原著　Goto K, Morimoto M, Osaki M, Tanio A, Izutsu R, Fujiwara Y, Okada F.
The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
BMC Cancer, 22, 1, 2022
10.1186/s12885-022-09339-0: https://pubmed.ncbi.nlm.nih.gov/35296279/

原著　Izutsu R, Osaki M, Nemoto H, Jingu M, Sasaki R, Yoshioka Y, Ochiya T, Okada F.
AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
Scientific Reports, 12, 1, 2022
10.1038/s41598-021-04662-1: https://www.nature.com/articles/s41598-021-04662-1

原著　Goto K, Osaki M, Izutsu R, Tanaka H, Sasaki R, Tanio A, Satofuka H, Kazuki Y, Yamamoto M, Kugoh H, Ito H, Oshimura M, Fujiwara Y,
Okada F.
Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer.
Diagnostic Pathology, 17, 1, 2022
10.1186/s13000-021-01176-2: https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-021-01176-2

原著　Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F.
MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis.
Molecular Medicine Reports, 25, 1, 2022
10.3892/mmr.2021.12527: https://doi.org/10.3892/mmr.2021.12527

原著　Nemoto H, Otake M, Matsumoto T, Izutsu R, Jehung J.P, Goto K, Osaki M, Mayama M, Shikanai M, Kobayashi H, Watanabe T, Okada F.
Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA).
Journal of Functional Foods, 88, 2022
10.1016/j.jff.2021.104907: https://doi.org/10.1016/j.jff.2021.104907

原著　Hoshino Y, Sugihara T, Ikeda S, Tarumoto R, Matsuki Y, Kanda T, Iyama T, Takata T, Matono T, Nagahara T, Okano J.-I, Ueki M, Koda M,
Osaki M, Okada F, Isomoto H.
Newly Invented Micellized Vitamin K2 Recovered Prolonged Prothrombin Time under Obstructive Jaundice in Rats with Bile Duct Ligation.
Journal of Nutritional Science and Vitaminology, 67, 6, 2021
10.3177/JNSV.67.397: https://doi.org/10.3177/jnsv.67.397

A03　川鍋　　陽

原著　Takunari Kiya, Kohei Takeshita, Akira Kawanabe, and Yuichiro Fujiwara.
Intermolecular functional coupling between phosphoinositides and the potassium channel KcsA.
J. Biol. Chem., Vol. 298(8), 102257, 2022
10.1016/j.jbc.2022.102257: https://doi.org/10.1016/j.jbc.2022.102257

A03　丸山　明子

原著　Kamasalath Soudthedlath, Toshiki Nakamura, Tsukasa Ushiwatari, Jutarou Fukazawa, Keishi Osakabe, Yuriko Osakabe, Akiko Maruyama-Nakashita.
SULTR2;1 adjusts the bolting timing by transporting sulfate from rosette leaves to the primary stem.
Plant Cell Physiol, in press , 2024
10.1093/pcp/pcae020

原著　Shunsuke Miyaji, Takehiro Ito, Taisuke Kitaiwa, Kosuke Nishizono, Shin-Ichiro Agake, Hiroki Harata, Haruna Aoyama, Minori Umahashi, Muneo Sato, Jun Inaba, Shinya Fushinobu, Tadashi Yokoyama, Akiko Maruyama-Nakashita, Masami Yokota Hirai, Naoko Ohkama-Ohtsu.
N2-Acetylornithine deacetylase functions as a Cys-Gly dipeptidase in the cytosolic glutathione degradation pathway in Arabidopsis thaliana.
Plant J, in press , 2024
10.1111/tpj.16700

原著　Y Iwamoto, S Saito, T Teramoto, A Maruyama-Nakashita, Y Kakuta.
Crystal structure of Arabidopsis thaliana sulfotransferase SOT16 involved in glucosinolate biosynthesis.
BBRC 677: 149-157, 2023
https://doi.org/10.1016/j.bbrc.2023.08.020

原著　L Zhang, R Kawaguchi, T Enomoto, S Nishida, M Burow, A Maruyama-Nakashita.
Glucosinolate catabolism maintains glucosinolate profiles and transport in sulfur-starved Arabidopsis.
Plant Cell Physiol. 64: in press, 2023
https://doi.org/10.1093/pcp/pcad075

原著　M Yasuda, M Fujita, K Soudthedlath, M Kusajima, H Takahashi, T Tanaka, F Narita, T Asami, A Maruyama-Nakashita, H Nakashita.
Characterization of disease resistance induced by a pyrazolecarboxylic acid derivative in Arabidopsis thaliana.
Int. J. Mol. Sci. 24: 9037, 2023
https://doi.org/10.3390/ijms24109037

原著　J Piotrowska, Y Jodoi, N.H Trang, A Wawrzynska, H Takahashi, A Sirko, A Maruyama-Nakashita*.
The C-terminal region of SLIM1 transcription factor is required for sulfur deficiency response.
Plants, 11, 2022
10.3390/plants11192595: https://doi.org/10.3390/plants11192595

原著　T Ito, T Kitaiwa, K Nishizono, M Umahashi, S Miyaji, S Agake, K Kuwahara, T Yokoyama, S Fushinobu, A Maruyama-Nakashita, R Sugiyama, M Sato, J Inaba, M.Y Hirai, N Ohkama-Ohtsu*.
Glutathione degradation activity of γ-Glutamyl Peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis.
Plant J, 111, 1626–1642, 2022
10.1111/tpj.15912: https://doi.org/10.1111/tpj.15912

原著　M Kusajima, M Fujita, K Soudthedlath, H Nakamura, K Yoneyama, T Nomura, K Akiyama, A Maruyama-Nakashita, T Asami, H Nakashita*.
Strigolactones modulate salicylic acid-mediated disease resistance in Arabidopsis thaliana.
Int. J. Mol. Sci., 23, 2022
10.3390/ijms23095246: https://doi.org/10.3390/ijms23095246

原著　H Li, A Suyama, N Mitani-Ueno, R Hell, A Maruyama-Nakashita*.
Low-level NaCl stimulates plant growth by improving carbon and sulfur assimilation in Arabidopsis thaliana.
Plants, 10, 2021
10.3390/plants10102138: https://doi.org/10.3390/plants10102138

総説　伊藤 岳洋、 張 柳、 大津(大鎌) 直子、 丸山 明子*
硫黄欠乏に対する植物の応答 〜適応のための内的動態〜
化学と生物, 60巻, 10号, 2022
https://katosei.jsbba.or.jp/index.php?aid=1621

A03　秋山　雅博

総説　Masahiro Akiyama, Jun Uchiyama, Yoshito Kumagai, Yun-Gi Kim.
Supersulfides to Regulate Electrophilic Stress.
akugaku Zasshi, 144(1):47-50, 2024
10.1248/yakushi.23-00162-2.

原著　Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biology, 57, 2022
10.1016/j.redox.2022.102514: https://doi.org/10.1016/j.redox.2022.102514

原著　Masahiro Akiyama, Yasuhiro Shinkai, Hiroto Yamakawa, Yun-Gi Kim, Yoshito Kumagai.
Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome.
Chemosphere, 299, 2022
10.1016/j.chemosphere.2022.134374: https://doi.org/10.1016/j.chemosphere.2022.134374

原著　Jun Uchiyama, Masahiro Akiyama, Koji Hase, Yoshito Kumagai, Yun-Gi Kim.
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species.
Cell reports, 38, 2022
10.1016/j.celrep.2022.110479: https://doi.org/10.1016/j.celrep.2022.110479

A03　三田　雄一郎

原著　Zhang W, Miura A, Abu Saleh MM, Shimizu K, Mita Y, Tanida R, Hirako S, Shioda S, Gmyr V, Kerr-Conte J, Pattou F, Jin C, Kanai Y, Sasaki K, Minamino N, Sakoda H, Nakazato M.
The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function.
Nat Commun, 14(1):8158, 2023
10.1038/s41467-023-43976-8.

原著　Mizuno A, Toyama T, Ichikawa A, Sakai N, Yoshioka Y, Nishito Y, Toga R, Amesaka H, Kaneko T, Arisawa K, Tsutsumi R, Mita Y, Tanaka S, Noguchi N, Saito Y.
An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase.
J Biol Chem, 299(8):105009, 2023
10.1016/j.jbc.2023.105009

原著　Kaneko T, Mita Y, Nozawa-Kumada K, Yazaki M, Arisawa M, Niki E, Noguchi N, Saito Y.
Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation.
Free Radic Res , 11;1-14, 2023
10.1080/10715762.2023.2165918.

B01　田原　淳士

原著　Phatchada Santawaja, Shinji Kudo, Atsushi Tahara, Shusaku Asano, Jun-ichiro Hayashi.
Dissolution of Iron Oxides Highly Loaded in Oxalic Acid Aqueous Solution for a Potential Application in Iron-Making.
ISIJ International, 62(12), 2466-2475, 2022
10.2355/isijinternational.isijint-2020-726

原著　Omar Falyouna, Ibrahim Maamoun, Khaoula Bensaida, Atsushi Tahara, Yuji Sugihara, Osama Eljamal.
Chemical deposition of iron nanoparticles (Fe0) on titanium nanowires for efficient adsorption of ciprofloxacin from water.
Wat. Prac. Tech., 17(1), 75-83, 2022
10.2166/wpt.2021.091

原著　Omar Falyouna, Ibrahim Maamoun, Khaoula Bensaida, Atsushi Tahara, Yuji Sugihara, Osama Eljamal.
Encapsulation of iron nanoparticles with magnesium hydroxide shell for remarkable removal of ciprofloxacin from contaminated water.
J. Colloid Interface Sci., 605, 813-827, 2022
10.1016/j.jcis.2021.07.154

原著　Tamer Shubair, Atsushi Tahara, Shahjalal Khandaker.
Optimizing the magnetic separation of strontium ion using modified zeolite with nano iron particles.
Case St. Chem. Env. Eng., 6, 2022
10.1016/j.cscee.2022.100243: https://doi.org/10.1016/j.cscee.2022.100243

原著　Omar Falyouna, Khaoula Bensaida, Ibrahim Maamoun, U.P.M Ashik, Atsushi Tahara, Kazuya Tanaka, Noboru Aoyagi, Yuji Sugihara,
Osama Eljamal.
Synthesis of hybrid magnesium hydroxide/magnesium oxide nanorods [Mg(OH)2/MgO] for prompt and efficient adsorption of ciprofloxacin from aqueous solutions.
J. Clean. Prod., 342(15), 2022
10.1016/j.jclepro.2022.130949: https://doi.org/10.1016/j.jclepro.2022.130949

原著　Takuya Kiyozumi, Shinji Kudo, Aska Mori, Riku Mizoguchi, Atsushi Tahara, Shusaku Asano, Jun-ichiro Hayashi.
Synthesis of Oxalate from CO2 and Cesium Carbonate Supported Over Porous Carbon.
ISIJ International, 62(12), 2022
10.2355/isijinternational.ISIJINT-2022-159: https://doi.org/10.2355/isijinternational.ISIJINT-2022-159

原著　Shusaku Asano, Samuel J. Adams, Yuta Tsuji, Kazunari Yoshizawa, Atsushi Tahara,Jun-ichiro Hayashi.
Homogeneous catalyst modifier for alkyne semi-hydrogenation: systematic screening in an automated flow reactor and computational study on mechanisms.
React. Chem. Eng., 7, 2022
10.1039/D2RE00147K: https://doi.org/10.1039/D2RE00147K

B01　小金澤　禎史

原著　Minako Okazaki, Masayuki Matsumoto & Tadachika Koganezawa.
Hydrogen sulfide production in the medullary respiratory center modulates the neural circuit for respiratory pattern and rhythm generations.
Scientific Reports, 13, 20046, 2023
https://doi.org/10.1038/s41598-023-47280-9

原著　Kiyotaka Nakamagoe, Shunya Matsumoto, Nozomi Touno, Ikumi Tateno & Tadachika Koganezawa.
Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis.
Neurological Sciences, 44(8), 2787-2793, 2023
https://doi.org/10.1007/s10072-023-06719-7

総説　岡﨑実那子、小金澤禎史
脳内の硫化水素は正常な呼吸の維持に必須
医学のあゆみ, 279(12,13), 1183-1184, 2021
https://www.pieronline.jp/content/article/0039-2359/279120/1183

B01　若杉　桂輔

原著　Takumi Yokosawa and Keisuke Wakasugi.
Tryptophan-starved human cells overexpressing tryptophanyl-tRNA synthetase enhance high-affinity tryptophan uptake via enzymatic production of tryptophanyl-AMP.
Int. J. Mol. Sci, 24, 15453, 2023
https://doi.org/10.3390/ijms242015453

B01　宮崎　亮次

原著　Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S. Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki.
YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition.
PLoS Biology, 22(4), 2024
10.1371/journal.pbio.3002601

原著　Ryoji Miyazaki, Yoshinori Akiyama.
Analyzing protein intermediate interactions in living E. coli cells using site-specific photo-crosslinking combined with chemical crosslinking.
STAR Protocols, 4(2), 2023
10.1016/j.xpro.2023.102178

原著　Ryoji Miyazaki, Mengting Ai, Natsuko Tanaka, Takehiro Suzuki, Naoshi Dhomae, Tomoya Tsukazaki, Yoshinori Akiyama,
Hiroyuki Mori.
Inner membrane YfgM–PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation.
J Biol Chem., 298(11), 2022
10.1016/j.jbc.2022.102572: https://doi.org/10.1016/j.jbc.2022.102572

B01　石井　　功

原著　Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii.
Different coactivator recruitment to human PPARα/δ/γ ligand-binding domains by eight PPAR agonists to treat nonalcoholic fatty liver disease.
Biomedicines, 12, 624, 2024
10.3390/biomedicines12030624

総説　Kazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, Masayuki Fuwa, Hiroyuki Morita.
Sphingosine 1-phosphate regulates obesity and glucose homeostasis.
Int. J. Mol. Sci, 25, 932 , 2024
10.3390/ijms25020932

原著　Manandhar, S. Chambers, S. Miller, A. Ishii, I. Bhatia, M.
Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells.
International journal of molecular sciences. 2023
24, https://www.mdpi.com/1422-0067/24/17/13650

総説　Kamata, S. Honda, A. Ishii, I.
Current clinical trial status and future prospects of PPAR-targeted drugs for treating nonalcoholic fatty liver disease.
Biomolecules 2023
13, https://www.mdpi.com/2218-273X/13/8/1264

原著　Kamata S, Honda A, Ishikawa R, Akahane M, Fujita A, Kaneko C, Miyawaki S, Habu Y, Shiiyama Y, Uchii K, Machida Y, Oyama T, Ishii I.
Functional and structural insights into the human PPARα/δ/γ targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor.
Antioxidants. 2023
12(8):1523 https://doi.org/10.3390/antiox12081523

原著　Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, and Akaike T.
Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism.
Antioxidants. 2023
12(4):868: https://doi.org/10.3390/antiox12040868

原著　Akahoshi N, Hasegawa R, Yamamoto S, Takemoto R, Yoshizawa T, Kamichatani W, Ishii I.
Differential roles of cystathionine gamma-lyase and mercaptopyruvate sulfurtransferase in hapten-induced colitis and contact dermatitis in mice.
Int. J. Mol. Sci. 2023
24(3):2659: https://doi.org/10.3390/ijms24032659

原著　Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H.
Opposing roles of sphingosine 1-phosphate receptors 1 and 2 in fat deposition and glucose tolerance in obese male mice.
International Journal of Molecular Sciences, 23, 2, 2022
Endocrionology. 2023;
164(3):1716–1726: https://doi.org/10.1210/endocr/bqad019

総説　Ishii I, Bhatia M.
Amino acids in health and disease: The good, the bad, and the ugly.
Int. J. Mol. Sci. 2023
24(5):4931: https://doi.org/10.3390/ijms24054931

原著　Ishii I, Kamata S, Ito S, Shimonaga A, Koizumi M, Tsushima M, Miura A, Nagata T, Tosaka Y, Ohtani H, Kamichatani W, Akahoshi N.
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
International Journal of Molecular Sciences, 23, 2, 2022
10.3390/ijms23020928: https://doi.org/10.3390/ijms23020928

原著　Murae M, Shimizu Y, Yamamoto Y, Kobayashi A, Houri M, Inoue T, Irie T, Gemba R, Kondo Y, Nakano Y, Miyazaki S, Yamada D, Saitoh A,
Ishii I, Onodera T, Takahashi Y, Wakita T, Fukasawa M, Noguchi K.
The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione.
Biochemical and Biophysical Research Communications, 597, 2022
10.1016/j.bbrc.2022.01.106: https://doi.org/10.1016/j.bbrc.2022.01.106

原著　Honda A, Kamata S, Akahane M, Machida Y, Uchii K, Shiiyama Y, Habu Y, Miyawaki S, Kaneko C, Oyama T, Ishii I.
Functional and Structural Insights into Human PPARα/δ/Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.
International Journal of Molecular Sciences, 23, 9, 2022
10.3390/ijms23094726: https://doi.org/10.3390/ijms23094726

原著　Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, Narita S, Shibata R, Ishii I, Calvert JW, et al.
Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K/Akt-dependent mechanism.
J Am Heart Assoc, 11, 2022
10.1161/JAHA.122.026889: https://www.ahajournals.org/doi/10.1161/JAHA.122.026889

総説　Kamata S, Ishii I.
PPARα-ligand binding modes revealed by X-ray crystallography.
Yakugaku zasshi, 141(11), 2021
10.1248/yakushi.21-00138: https://doi.org/10.1248/yakushi.21-00138

総説　Honda A, Ishii I.
The perspective of PPAR dual/pan agonists as therapeutic drugs against NAFLD.
Yakugaku zasshi, 142(12), 2022
10.1248/yakushi.22-00159-1: https://doi.org/10.1248/yakushi.22-00159-1